Fund Universe

BAKER BROS. ADVISORS LP

CIK 0001263508 · holdings for 2026Q2 (change vs 2026Q1) · in signal universe
Quality Q
0.959
AUM ($M)
19,955
Positions
84
Turnover
0.12
Top-10 wt
73%
Herfindahl
0.076
History (qtrs)
6
Excess Return

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Security type

Holdings · 92 positions · portfolio value $19,955M

TickerNameActivitySecurity Type WeightΔ Weight Value ($M)SharesΔ Shares Qtrs HeldExcess Return
INCY funds › Incyte Corporation ADD 17.5% +0.9% 3,487.2 30,762,330 +17,918 5
ONC funds › BeOne Medicines Ltd. ADD 12.6% -2.4% 2,508.2 8,801,567 +2,514 5
RVMD funds › Revolution Medicines, Inc. ADD 10.7% +5.4% 2,143.1 11,443,357 +1,888,000 5
MDGL funds › Madrigal Pharmaceuticals, Inc. ADD 5.8% -0.7% 1,150.8 2,143,131 +1,430 5
ACAD funds › ACADIA Pharmaceuticals Inc. ADD 5.4% -0.0% 1,085.7 42,912,904 +16,214 5
KYMR funds › Kymera Therapeutics, Inc. HOLD 5.0% +0.8% 992.7 8,657,242 +0 5
INSM funds › Insmed Incorporated ADD 4.7% -2.3% 937.8 8,796,111 +1,375,000 5
CELC funds › Celcuity Inc. HOLD 4.2% -1.0% 828.2 7,915,792 +0 5
KOD funds › Kodiak Sciences Inc. HOLD 3.9% -0.5% 776.1 19,919,186 +0 5
RYTM funds › Rhythm Pharmaceuticals, Inc. HOLD 3.1% +0.3% 622.3 5,604,483 +0 5
PRAX funds › Praxis Precision Medicines, Inc. HOLD 2.9% -0.3% 587.0 1,753,198 +0 5
ALKS funds › Alkermes plc HOLD 2.6% +0.6% 524.6 10,012,267 +0 5
SMMT funds › Summit Therapeutics Inc. TRIM 2.4% -1.6% 477.7 32,786,348 -3,604,715 5
GRAL funds › GRAIL, Inc. HOLD 1.4% +0.2% 275.0 4,028,614 +0 5
ABCL funds › AbCellera Biologics Inc. ADD 1.3% +0.7% 259.1 33,012,138 +2,736,200 5
IMVT funds › Immunovant, Inc. TRIM 1.0% +0.3% 209.4 5,435,220 -22,661 5
IDYA funds › IDEAYA Biosciences, Inc. ADD 0.9% +0.2% 186.7 5,010,030 +1,063,515 5
KNSA funds › Kiniksa Pharmaceuticals International, plc ADD 0.9% +0.1% 181.3 2,834,643 +8,397 5
CUSIP:G76279101 funds › Roivant Sciences Ltd. TRIM 0.8% +0.1% 166.9 4,716,831 -150,892 5
ARWR funds › Arrowhead Pharmaceuticals, Inc. HOLD 0.8% +0.1% 162.4 1,992,783 +0 5
IONS funds › Ionis Pharmaceuticals, Inc. HOLD 0.8% -0.1% 162.4 2,047,727 +0 4
EWTX funds › Edgewise Therapeutics, Inc. TRIM 0.8% -0.4% 150.4 3,701,719 -2,874,221 5
REPL funds › Replimune Group, Inc. HOLD 0.6% +0.1% 122.3 11,045,336 +0 5
NRIX funds › Nurix Therapeutics, Inc. HOLD 0.6% +0.2% 113.0 4,658,556 +0 5
STOK funds › Stoke Therapeutics, Inc. HOLD 0.5% -0.1% 109.2 3,336,697 +0 5
GLUE funds › Monte Rosa Therapeutics, Inc. HOLD 0.5% +0.1% 105.2 4,345,736 +0 5
IMTX funds › Immatics N.V. TRIM 0.5% -0.1% 96.3 9,508,565 -1,408,128 5
DNLI funds › Denali Therapeutics Inc. ADD 0.5% +0.1% 96.0 3,734,336 +2,641 5
CRNX funds › Crinetics Pharmaceuticals, Inc. HOLD 0.4% -0.0% 88.0 2,351,465 +0 5
DNTH funds › Dianthus Therapeutics, Inc. HOLD 0.4% +0.0% 83.1 852,164 +0 5
GPCR funds › Structure Therapeutics Inc. HOLD 0.4% -0.0% 76.9 1,432,529 +0 5
CUSIP:15102KAA8 funds › Celcuity Inc. HOLD 0.3% -0.1% 69.2 30,750,000 +0 4
RAPP funds › Rapport Therapeutics, Inc. HOLD 0.3% +0.0% 64.5 1,547,090 +0 5
ALMS funds › Alumis Inc. HOLD 0.3% +0.0% 56.6 2,012,500 +0 5
PRLD funds › Prelude Therapeutics Inc. HOLD 0.3% +0.1% 54.0 10,123,824 +0 5
RLAY funds › Relay Therapeutics, Inc. ADD 0.3% +0.2% 52.9 2,826,783 +1,666,666 5
MIRM funds › Mirum Pharmaceuticals, Inc. HOLD 0.3% +0.0% 52.2 445,975 +0 2
BCYC funds › Bicycle Therapeutics plc HOLD 0.2% -0.1% 46.2 10,885,357 +0 5
ELVN funds › Enliven Therapeutics, Inc. HOLD 0.2% +0.0% 45.9 905,191 +0 5
CLDX funds › Celldex Therapeutics, Inc. ADD 0.2% +0.1% 44.0 1,182,611 +517,241 5
VRDN funds › Viridian Therapeutics, Inc. ADD 0.2% -0.0% 43.8 2,383,025 +411,347 5
DSGN funds › Design Therapeutics, Inc. ADD 0.2% +0.0% 38.8 2,678,430 +92,452 5
TRDA funds › Entrada Therapeutics, Inc. HOLD 0.2% -0.2% 37.3 5,072,730 +0 5
FTH funds › Faeth Therapeutics, Inc. NEW 0.2% +0.2% 32.2 1,286,411 +1,286,411 1
AKTS funds › Aktis Oncology, Inc. HOLD 0.2% +0.1% 32.1 996,351 +0 2
NGNE funds › Neurogene Inc. HOLD 0.2% +0.0% 31.2 991,691 +0 5
JBIO funds › Jade Biosciences, Inc. TRIM 0.1% +0.0% 27.3 1,230,426 -410,711 3
TSHA funds › Taysha Gene Therapies, Inc. HOLD 0.1% +0.0% 27.3 4,004,756 +0 5
RCUS funds › Arcus Biosciences, Inc. ADD 0.1% +0.1% 26.0 844,816 +429,195 3
IRON funds › Disc Medicine, Inc. HOLD 0.1% -0.0% 25.6 349,657 +0 5
ABSI funds › Absci Corporation HOLD Common Stock 0.1% +0.1% 24.7 2,134,803 +0 3
GENB funds › Generate Biomedicines, Inc. HOLD 0.1% +0.0% 24.0 1,423,602 +0 2
DBVT funds › DBV Technologies S.A. HOLD 0.1% -0.1% 24.0 1,461,425 +0 5
XENE funds › Xenon Pharmaceuticals Inc. HOLD 0.1% -0.0% 22.3 370,208 +0 5
TECX funds › Tectonic Therapeutic, Inc. HOLD 0.1% -0.0% 20.9 607,788 +0 5
CERS funds › Cerus Corporation TRIM 0.1% -0.0% 18.7 6,395,431 -3,612,914 5
CTMX funds › CytomX Therapeutics, Inc. HOLD 0.1% -0.0% 18.7 4,975,826 +0 5
DYN funds › Dyne Therapeutics, Inc. HOLD 0.1% +0.0% 18.1 813,449 +0 3
CYTK funds › Cytokinetics, Incorporated NEW 0.1% +0.1% 18.0 211,267 +211,267 1
XNCR funds › Xencor, Inc. HOLD 0.1% +0.0% 17.7 1,102,106 +0 5
SION funds › Sionna Therapeutics, Inc. HOLD 0.1% -0.0% 17.6 400,000 +0 5
NTLA funds › Intellia Therapeutics, Inc. NEW 0.1% +0.1% 15.7 930,232 +930,232 1
PBLS funds › Parabilis Medicines, Inc. NEW 0.1% +0.1% 13.7 500,000 +500,000 1
MPLT funds › MapLight Therapeutics, Inc. HOLD 0.1% +0.0% 13.1 364,705 +0 3
AVLN funds › Avalyn Pharma Inc. NEW 0.1% +0.1% 11.5 350,000 +350,000 1
EVMN funds › Evommune, Inc. HOLD 0.1% -0.1% 11.3 847,390 +0 2
BNTX funds › BioNTech SE HOLD 0.1% -0.0% 11.1 119,743 +0 5
TNGX funds › Tango Therapeutics, Inc. NEW 0.1% +0.1% 10.4 333,333 +333,333 1
AVTX funds › Avalo Therapeutics, Inc. NEW 0.1% +0.1% 10.2 550,000 +550,000 1
SERA funds › Sera Prognostics, Inc. HOLD 0.1% -0.0% 10.0 5,498,170 +0 5
VSTM funds › Verastem, Inc. ADD 0.0% +0.0% 9.5 2,499,338 +1,914,581 2
SGMT funds › Sagimet Biosciences Inc. HOLD 0.0% +0.0% 7.4 952,996 +0 5
EIKN funds › Eikon Therapeutics, Inc. HOLD 0.0% +0.0% 7.2 555,555 +0 2
LBRX funds › LB Pharmaceuticals Inc. HOLD 0.0% +0.0% 6.5 200,000 +0 4
VTVT funds › vTv Therapeutics, Inc. HOLD 0.0% -0.0% 5.6 148,314 +0 5
WVE funds › Wave Life Sciences Ltd. HOLD 0.0% -0.0% 4.8 822,638 +0 5
TARA funds › Protara Therapeutics, Inc. HOLD 0.0% -0.0% 3.7 971,614 +0 5
TCRX funds › TScan Therapeutics, Inc. HOLD 0.0% -0.0% 2.7 2,784,792 +0 5
IMNM funds › Immunome, Inc. NEW 0.0% +0.0% 1.2 55,306 +55,306 1
SKYE funds › Skye Bioscience, Inc. HOLD 0.0% -0.0% 1.1 1,575,243 +0 5
SANA funds › Sana Biotechnology, Inc. HOLD 0.0% +0.0% 1.1 310,483 +0 5
ALGS funds › Aligos Therapeutics, Inc. HOLD 0.0% -0.0% 0.5 83,055 +0 5
TYRA funds › Tyra Biosciences, Inc. HOLD 0.0% -0.0% 0.3 10,607 +0 5
CUSIP:86889P117 funds › Surrozen, Inc. Warrants @ $172.50 8/11/2026 (15 FOR 1) HOLD 0.0% -0.0% 0.0 833,333 +0 5
CTNM funds › Contineum Therapeutics, Inc. EXIT 0.0% -0.1% 0.0 0 -1,420,838 0
ARGX funds › argenx SE EXIT 0.0% -0.1% 0.0 0 -25,174 0
PHVS funds › Pharvaris N.V. EXIT 0.0% -0.1% 0.0 0 -375,000 0
CMPS funds › COMPASS Pathways plc EXIT 0.0% -0.1% 0.0 0 -2,344,720 0
ABVX funds › Abivax S.A. EXIT 0.0% -0.6% 0.0 0 -875,796 0
CUSIP:152309100 funds › Centessa Pharmaceuticals plc EXIT 0.0% -0.2% 0.0 0 -670,751 0
SYRE funds › Spyre Therapeutics, Inc. EXIT 0.0% -0.3% 0.0 0 -1,000,000 0
IMCR funds › Immunocore Holdings plc EXIT 0.0% -0.1% 0.0 0 -734,397 0

Point-in-time history

Each row is this fund as of that period, not as of today — what the scoring for that quarter actually saw.
PeriodAUM ($M)Positions TurnoverTop-10 wtHerfindahl Quality Q Skill Universe
2026Q2 19,955 84 0.12 73% 0.076 0.958 in
2026Q1 17,416 84 0.07 73% 0.076 0.971 in
2025Q4 17,079 86 0.13 74% 0.081 0.946 in
2025Q3 13,839 91 0.10 79% 0.105 0.960 in
2025Q2 10,308 89 0.12 82% 0.110 0.956 entered
2025Q1 9,037 89 0.00 82% 0.133 0.000 out
Long US-equity 13F disclosures only · up to 45-day reporting lag · sells = reduce/avoid, not short. JSON: /api/signals · /api/funds · /api/status