☆SPHERA FUNDS MANAGEMENT LTD.
Quality Q
0.149
AUM ($M)
699
Positions
97
Turnover
0.25
Top-10 wt
36%
Herfindahl
0.022
History (qtrs)
6
Excess Return
+37.5%
AI Eval Run AI Eval
Holdings · 114 positions · portfolio value $699M
| Ticker | Name | Activity | Security Type | Weight | Δ Weight | Value ($M) | Shares | Δ Shares | Qtrs Held | Excess Return |
|---|---|---|---|---|---|---|---|---|---|---|
| ☆TEVA funds › | TEVA PHARMACEUTICAL INDS LTD | ADD | — | 7.3% | +1.4% | 50.8 | 1,500,082 | +363,107 | 5 | — |
| ☆MLYS funds › | MINERALYS THERAPEUTICS INC | ADD | — | 5.7% | -0.6% | 39.7 | 1,469,971 | +130,000 | 5 | — |
| ☆TSEM funds › | TOWER SEMICONDUCTOR LTD | TRIM | — | 4.0% | -0.4% | 28.2 | 108,265 | -37,470 | 5 | — |
| ☆SNDX funds › | SYNDAX PHARMACEUTICALS INC | ADD | — | 3.2% | +0.3% | 22.2 | 1,014,606 | +290,043 | 5 | — |
| ☆BIIB funds › | BIOGEN INC | ADD | — | 3.0% | +0.1% | 20.9 | 96,626 | +4,100 | 5 | — |
| ☆RARE funds › | ULTRAGENYX PHARMACEUTICAL IN | TRIM | — | 2.8% | -0.1% | 19.6 | 588,494 | -220,839 | 5 | — |
| ☆BMRN funds › | BIOMARIN PHARMACEUTICAL INC | ADD | — | 2.7% | +1.3% | 18.8 | 328,550 | +188,650 | 3 | +8.8% |
| ☆CYTK funds › | CYTOKINETICS INC | ADD | — | 2.7% | +2.2% | 18.7 | 219,987 | +180,170 | 5 | — |
| ☆BBIO funds › | BRIDGEBIO PHARMA INC | ADD | — | 2.6% | -0.5% | 18.3 | 245,346 | +100 | 5 | — |
| ☆COGT funds › | COGENT BIOSCIENCES INC | ADD | — | 2.5% | -0.2% | 17.8 | 459,340 | +43,000 | 5 | — |
| ☆NVMI funds › | NOVA LTD | TRIM | — | 2.0% | -2.0% | 13.7 | 25,169 | -28,197 | 5 | — |
| ☆INSM funds › | INSMED INC | NEW | — | 1.8% | +1.8% | 12.7 | 118,800 | +118,800 | 1 | +57.5% |
| ☆MAZE funds › | MAZE THERAPEUTICS INC | ADD | — | 1.8% | +0.6% | 12.5 | 417,564 | +190,221 | 5 | — |
| ☆AZN funds › | ASTRAZENECA PLC | HOLD | — | 1.7% | -0.4% | 11.9 | 62,530 | +0 | 2 | -75.4% |
| ☆SNY funds › | SANOFI SA | HOLD | — | 1.6% | -0.6% | 11.5 | 269,515 | +0 | 5 | — |
| ☆HELP funds › | CYBIN INC | ADD | — | 1.5% | +0.7% | 10.7 | 1,620,753 | +633,663 | 5 | — |
| ☆LLY funds › | ELI LILLY & CO | TRIM | — | 1.4% | -0.0% | 9.6 | 8,040 | -1,000 | 5 | — |
| ☆MDGL funds › | MADRIGAL PHARMACEUTICALS INC | ADD | — | 1.3% | +0.5% | 9.4 | 17,419 | +8,379 | 3 | -35.6% |
| ☆TRVI funds › | TREVI THERAPEUTICS INC | TRIM | — | 1.3% | +0.2% | 9.3 | 499,029 | -75,000 | 5 | +105.8% |
| ☆ACAD funds › | ACADIA PHARMACEUTICALS INC | ADD | — | 1.3% | +0.3% | 9.0 | 356,534 | +100,332 | 5 | -4.3% |
| ☆CLDX funds › | CELLDEX THERAPEUTICS INC NEW | TRIM | — | 1.3% | -0.0% | 9.0 | 240,868 | -2,707 | 5 | — |
| ☆RYTM funds › | RHYTHM PHARMACEUTICALS INC | NEW | — | 1.3% | +1.3% | 8.9 | 80,400 | +80,400 | 1 | +202.2% |
| ☆ORIC funds › | ORIC PHARMACEUTICALS INC | ADD | — | 1.2% | -0.0% | 8.2 | 752,983 | +215,355 | 5 | — |
| ☆LRCX funds › | LAM RESEARCH CORP | NEW | — | 1.1% | +1.1% | 8.0 | 18,470 | +18,470 | 1 | +86.3% |
| ☆AMAT funds › | APPLIED MATLS INC | NEW | — | 1.1% | +1.1% | 8.0 | 11,040 | +11,040 | 1 | +110.2% re-entry |
| ☆TNGX funds › | TANGO THERAPEUTICS INC | TRIM | — | 1.1% | -0.1% | 7.9 | 254,250 | -89,313 | 3 | +359.5% |
| ☆NVS funds › | NOVARTIS AG | ADD | — | 1.1% | +0.1% | 7.8 | 50,000 | +13,000 | 5 | — |
| ☆CUSIP:83417MAE4 funds › | SOLAREDGE TECHNOLOGIES INC | HOLD | — | 1.1% | -0.1% | 7.7 | 4,000,000 | +0 | 4 | — |
| ☆VOR funds › | VOR BIOPHARMA INC | ADD | — | 1.1% | +0.1% | 7.7 | 416,417 | +94,500 | 3 | +183.8% |
| ☆ABBV funds › | ABBVIE INC | HOLD | — | 1.1% | -0.0% | 7.6 | 30,256 | +0 | 5 | — |
| ☆MRK funds › | MERCK & CO INC | ADD | — | 1.1% | +0.1% | 7.5 | 58,600 | +10,000 | 5 | — |
| ☆JNJ funds › | JOHNSON & JOHNSON | HOLD | — | 1.0% | -0.2% | 7.3 | 28,831 | +0 | 5 | — |
| ☆IDYA funds › | IDEAYA BIOSCIENCES INC | NEW | — | 1.0% | +1.0% | 7.3 | 196,408 | +196,408 | 1 | +155.9% re-entry |
| ☆IMTX funds › | IMMATICS N.V | ADD | — | 1.0% | -0.1% | 7.3 | 720,057 | +23,952 | 5 | — |
| ☆NVCT funds › | NUVECTIS PHARMA INC | NEW | — | 1.0% | +1.0% | 7.0 | 382,945 | +382,945 | 1 | +1084.9% |
| ☆PFE funds › | PFIZER INC | ADD | — | 1.0% | +0.1% | 6.9 | 286,000 | +100,000 | 5 | — |
| ☆HRMY funds › | HARMONY BIOSCIENCES HLDGS IN | NEW | — | 0.9% | +0.9% | 6.4 | 176,663 | +176,663 | 1 | +152.5% |
| ☆XENE funds › | XENON PHARMACEUTICALS INC | TRIM | — | 0.9% | -0.4% | 6.3 | 105,000 | -22,000 | 2 | +97.2% |
| ☆CLYM funds › | CLIMB BIO INC | ADD | — | 0.9% | +0.4% | 6.3 | 483,747 | +64,500 | 5 | — |
| ☆ZBIO funds › | ZENAS BIOPHARMA INC | ADD | — | 0.8% | +0.1% | 5.9 | 230,834 | +16,500 | 2 | -9.4% |
| ☆NVO funds › | NOVO-NORDISK A S | HOLD | — | 0.8% | +0.1% | 5.8 | 120,677 | +0 | 5 | — |
| ☆ELVN funds › | ENLIVEN THERAPEUTICS INC | TRIM | — | 0.8% | -0.2% | 5.7 | 112,765 | -40,500 | 5 | — |
| ☆PRLD funds › | PRELUDE THERAPEUTICS INC | ADD | — | 0.8% | +0.4% | 5.4 | 1,019,832 | +461,493 | 3 | +391.5% |
| ☆GSK funds › | GSK PLC | TRIM | — | 0.8% | -0.4% | 5.3 | 102,000 | -20,000 | 5 | — |
| ☆FBRX funds › | FORTE BIOSCIENCES INC | ADD | — | 0.8% | -0.1% | 5.3 | 249,693 | +64,709 | 5 | — |
| ☆BIOA funds › | BIOAGE LABS INC | ADD | — | 0.7% | +0.5% | 5.2 | 213,671 | +127,153 | 3 | +14.5% |
| ☆SRRK funds › | SCHOLAR ROCK HLDG CORP | HOLD | — | 0.7% | -0.1% | 5.2 | 94,265 | +0 | 3 | +39.3% re-entry |
| ☆MSLE funds › | SATELLOS BIOSCIENCE INC | ADD | — | 0.7% | +0.3% | 5.1 | 652,590 | +163,383 | 2 | -61.5% |
| ☆PALI funds › | PALISADE BIO INC | ADD | — | 0.7% | +0.2% | 4.7 | 2,257,106 | +523,635 | 3 | -19.9% |
| ☆ELDN funds › | ELEDON PHARMACEUTICALS INC | TRIM | — | 0.7% | -0.3% | 4.7 | 1,191,187 | -580,944 | 5 | — |
| ☆VST funds › | VISTRA CORP | NEW | — | 0.7% | +0.7% | 4.7 | 29,450 | +29,450 | 1 | +15.9% |
| ☆TLN funds › | TALEN ENERGY CORP | NEW | — | 0.7% | +0.7% | 4.7 | 12,135 | +12,135 | 1 | +35.1% |
| ☆SVRA funds › | SAVARA INC | ADD | — | 0.7% | -0.0% | 4.7 | 756,164 | +17,000 | 5 | — |
| ☆IRON funds › | DISC MEDICINE INC | ADD | — | 0.7% | +0.1% | 4.6 | 63,538 | +10,000 | 2 | +14.4% |
| ☆CLOU funds › | GLOBAL X FDS | NEW | — | 0.6% | +0.6% | 4.5 | 195,900 | +195,900 | 1 | +131.3% |
| ☆DYN funds › | DYNE THERAPEUTICS INC | ADD | — | 0.6% | +0.1% | 4.4 | 199,594 | +39,000 | 5 | — |
| ☆RLAY funds › | RELAY THERAPEUTICS INC | TRIM | — | 0.6% | -0.1% | 4.4 | 233,836 | -174,600 | 2 | +357.8% |
| ☆AVTX funds › | AVALO THERAPEUTICS INC | NEW | — | 0.6% | +0.6% | 4.3 | 232,294 | +232,294 | 1 | +98.0% |
| ☆PMN funds › | PROMIS NEUROSCIENCES INC | HOLD | — | 0.6% | -0.1% | 4.3 | 325,591 | +0 | 3 | +72.6% |
| ☆BCRX funds › | BIOCRYST PHARMACEUTICALS INC | TRIM | — | 0.6% | -0.8% | 4.2 | 422,051 | -444,413 | 3 | +30.9% |
| ☆RVMD funds › | REVOLUTION MEDICINES INC | TRIM | — | 0.6% | -0.3% | 4.2 | 22,400 | -32,710 | 4 | +442.1% |
| ☆CABA funds › | CABALETTA BIO INC | NEW | — | 0.6% | +0.6% | 4.1 | 1,329,012 | +1,329,012 | 1 | -76.7% |
| ☆GENB funds › | GENERATE BIOMEDICINES INC | ADD | — | 0.6% | +0.2% | 4.1 | 245,000 | +60,000 | 2 | +24.9% |
| ☆MDWD funds › | MEDIWOUND LTD | HOLD | — | 0.6% | -0.2% | 4.0 | 273,192 | +0 | 4 | -47.2% |
| ☆ACOG funds › | ALPHA COGNITION INC | TRIM | — | 0.6% | +0.0% | 3.9 | 545,816 | -21,800 | 5 | — |
| ☆WVE funds › | WAVE LIFE SCIENCES LTD | ADD | — | 0.5% | -0.2% | 3.7 | 638,272 | +90,000 | 4 | -66.8% |
| ☆CRVS funds › | CORVUS PHARMACEUTICALS INC | TRIM | — | 0.5% | -0.1% | 3.7 | 244,961 | -3,000 | 5 | — |
| ☆OVID funds › | OVID THERAPEUTICS INC | TRIM | — | 0.5% | -0.1% | 3.6 | 1,353,000 | -269,828 | 2 | +274.3% |
| ☆BBOT funds › | BRIDGEBIO ONCOLOGY THERAPEUT | NEW | — | 0.5% | +0.5% | 3.5 | 460,985 | +460,985 | 1 | -8.7% |
| ☆CTMX funds › | CYTOMX THERAPEUTICS INC. | ADD | — | 0.5% | +0.3% | 3.3 | 879,000 | +659,000 | 2 | -91.8% |
| ☆PRQR funds › | PROQR THRAPEUTICS N V | NEW | — | 0.5% | +0.5% | 3.3 | 1,757,458 | +1,757,458 | 1 | +146.8% |
| ☆ALNY funds › | ALNYLAM PHARMACEUTICALS INC | NEW | — | 0.5% | +0.5% | 3.3 | 10,800 | +10,800 | 1 | -84.9% |
| ☆KURA funds › | KURA ONCOLOGY INC | TRIM | — | 0.5% | +0.0% | 3.2 | 295,039 | -483 | 5 | — |
| ☆KOD funds › | KODIAK SCIENCES INC | TRIM | — | 0.5% | -0.3% | 3.2 | 81,796 | -33,000 | 3 | +145.7% |
| ☆ORA funds › | ORMAT TECHNOLOGIES INC | TRIM | — | 0.4% | -0.9% | 3.1 | 28,015 | -40,235 | 2 | -46.2% re-entry |
| ☆CTNM funds › | CONTINEUM THERAPEUTICS INC | ADD | — | 0.4% | +0.0% | 3.0 | 183,475 | +10,000 | 3 | +14.1% |
| ☆LRMR funds › | LARIMAR THERAPEUTICS INC | NEW | — | 0.4% | +0.4% | 2.8 | 926,004 | +926,004 | 1 | +218.6% re-entry |
| ☆IMMX funds › | IMMIX BIOPHARMA INC | NEW | — | 0.4% | +0.4% | 2.8 | 270,000 | +270,000 | 1 | +104.2% |
| ☆AMGN funds › | AMGEN INC | HOLD | — | 0.4% | -0.1% | 2.7 | 7,500 | +0 | 5 | — |
| ☆BHVN funds › | BIOHAVEN LTD | TRIM | — | 0.4% | -0.5% | 2.4 | 164,437 | -429,563 | 2 | +33.2% re-entry |
| ☆CEG funds › | CONSTELLATION ENERGY CORP | NEW | — | 0.4% | +0.4% | 2.4 | 9,850 | +9,850 | 1 | +12.4% |
| ☆VSTM funds › | VERASTEM INC | ADD | — | 0.3% | +0.0% | 2.4 | 632,632 | +288,954 | 5 | -36.2% |
| ☆TENX funds › | TENAX THERAPEUTICS INC | TRIM | — | 0.3% | -0.1% | 1.7 | 120,200 | -15,815 | 3 | -109.6% |
| ☆TSHA funds › | TAYSHA GENE THERAPIES INC | NEW | — | 0.2% | +0.2% | 1.7 | 250,000 | +250,000 | 1 | +20.2% re-entry |
| ☆GPCR funds › | STRUCTURE THERAPEUTICS INC | TRIM | — | 0.2% | -0.2% | 1.5 | 28,600 | -22,200 | 5 | — |
| ☆UPB funds › | UPSTREAM BIO INC | TRIM | — | 0.2% | -0.3% | 1.5 | 219,700 | -138,300 | 2 | -60.1% |
| ☆VYGR funds › | VOYAGER THERAPEUTICS INC | TRIM | — | 0.2% | -0.1% | 1.5 | 427,554 | -42,207 | 4 | -34.4% |
| ☆ORGO funds › | ORGANOGENESIS HLDGS INC | HOLD | — | 0.2% | -0.0% | 1.3 | 550,000 | +0 | 2 | -109.5% |
| ☆IKT funds › | INHIBIKASE THERAPEUTICS INC | NEW | — | 0.2% | +0.2% | 1.3 | 649,309 | +649,309 | 1 | +409.2% |
| ☆CUSIP:231269309 funds › | CURIS INC | TRIM | — | 0.1% | -0.0% | 1.0 | 98,996 | -1,895,941 | 2 | — |
| ☆STTK funds › | SHATTUCK LABS INC | TRIM | — | 0.1% | -0.2% | 0.6 | 86,461 | -194,325 | 3 | +472.7% |
| ☆TRAX funds › | FIRST TRACKS BIOTHERAPEUTICS | NEW | — | 0.1% | +0.1% | 0.6 | 27,876 | +27,876 | 1 | +4180.6% |
| ☆SKYE funds › | SKYE BIOSCIENCE INC | HOLD | — | 0.1% | -0.0% | 0.5 | 678,928 | +0 | 5 | — |
| ☆TRAW funds › | TRAWS PHARMA INC | NEW | — | 0.0% | +0.0% | 0.3 | 398,486 | +398,486 | 1 | -123.3% |
| ☆EVMN funds › | EVOMMUNE INC | TRIM | — | 0.0% | -0.3% | 0.3 | 22,632 | -55,602 | 3 | -56.4% |
| ☆HOWL funds › | WEREWOLF THERAPEUTICS INC | HOLD | — | 0.0% | -0.1% | 0.2 | 626,810 | +0 | 5 | — |
| ☆APRE funds › | APREA THERAPEUTICS INC | HOLD | — | 0.0% | -0.0% | 0.2 | 270,000 | +0 | 5 | — |
| ☆CAMT funds › | CAMTEK LTD | EXIT | — | 0.0% | -1.4% | 0.0 | 0 | -53,020 | 0 | — |
| ☆CUSIP:03152W109 funds › | AMICUS THERAPEUTIC | EXIT | — | 0.0% | -1.5% | 0.0 | 0 | -603,377 | 0 | — |
| ☆CLBT funds › | CELLEBRITE DI LTD | EXIT | — | 0.0% | -1.5% | 0.0 | 0 | -631,521 | 0 | -56.8% re-entry |
| ☆BMY funds › | BRISTOL-MYERS SQUIBB CO | EXIT | — | 0.0% | -0.2% | 0.0 | 0 | -17,500 | 0 | — |
| ☆IBIT funds › | ISHARES BITCOIN TRUST ETF | EXIT | — | 0.0% | -0.4% | 0.0 | 0 | -59,505 | 0 | — |
| ☆NICE funds › | NICE LTD | EXIT | — | 0.0% | -0.1% | 0.0 | 0 | -5,611 | 0 | -50.9% re-entry |
| ☆FHTX funds › | FOGHORN THERAPEUTICS INC | EXIT | — | 0.0% | -0.0% | 0.0 | 0 | -12,224 | 0 | -117.3% |
| ☆CUSIP:03753U106 funds › | APELLIS PHARMACEUTICALS INC | EXIT | — | 0.0% | -1.5% | 0.0 | 0 | -214,914 | 0 | — |
| ☆ZIM funds › | ZIM INTEGRATED SHIPPING SERV | EXIT | — | 0.0% | -0.5% | 0.0 | 0 | -105,950 | 0 | +118.9% |
| ☆DTIL funds › | PRECISION BIOSCIENCES INC | EXIT | — | 0.0% | -0.0% | 0.0 | 0 | -40,000 | 0 | +59.1% |
| ☆CUSIP:834203309 funds › | SOLENO THERAPEUTICS INC | EXIT | — | 0.0% | -1.2% | 0.0 | 0 | -216,281 | 0 | — |
| ☆SEDG funds › | SOLAREDGE TECHNOLOGIES INC | EXIT | — | 0.0% | -0.5% | 0.0 | 0 | -52,836 | 0 | — |
| ☆PANW funds › | PALO ALTO NETWORKS INC | EXIT | — | 0.0% | -1.5% | 0.0 | 0 | -52,800 | 0 | +399.3% re-entry |
| ☆ENPH funds › | ENPHASE ENERGY INC | EXIT | — | 0.0% | -0.9% | 0.0 | 0 | -142,419 | 0 | +38.6% |
| ☆AAOI funds › | APPLIED OPTOELECTRONICS INC | EXIT | — | 0.0% | -1.1% | 0.0 | 0 | -73,400 | 0 | +26122.1% |
| ☆AMZN funds › | AMAZON COM INC | EXIT | — | 0.0% | -1.1% | 0.0 | 0 | -31,940 | 0 | +166.4% re-entry |
| ☆CUSIP:04351P101 funds › | ASCENDIS PHARMA A/S | EXIT | — | 0.0% | -0.3% | 0.0 | 0 | -8,000 | 0 | — |
Point-in-time history
| Period | AUM ($M) | Positions | Turnover | Top-10 wt | Herfindahl | Quality Q | Skill | Universe |
|---|---|---|---|---|---|---|---|---|
| 2026Q2 | 699 | 97 | 0.25 | 36% | 0.022 | 0.148 | — | in |
| 2026Q1 | 581 | 92 | 0.28 | 37% | 0.022 | 0.126 | — | in |
| 2025Q4 | 479 | 94 | 0.33 | 34% | 0.021 | 0.053 | — | in |
| 2025Q3 | 422 | 101 | 0.31 | 37% | 0.023 | 0.065 | — | in |
| 2025Q2 | 382 | 101 | 0.26 | 35% | 0.022 | 0.099 | — | entered |
| 2025Q1 | 405 | 112 | 0.00 | 35% | 0.020 | 0.000 | — | out |
Long US-equity 13F disclosures only · up to 45-day reporting lag · sells = reduce/avoid, not short.
JSON: /api/signals ·
/api/funds ·
/api/status