Fund Universe

Siren, L.L.C.

CIK 0002005245 · holdings for 2026Q2 (change vs 2026Q1) · in signal universe
Quality Q
0.594
AUM ($M)
4,926
Positions
115
Turnover
0.20
Top-10 wt
45%
Herfindahl
0.032
History (qtrs)
6
Excess Return

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Quarter
Activity this period
Security type

Holdings · 125 positions · portfolio value $4,926M

TickerNameActivitySecurity Type WeightΔ Weight Value ($M)SharesΔ Shares Qtrs HeldExcess Return
SRRK funds › Scholar Rock Holding Corp TRIM 10.7% -4.1% 526.6 9,575,013 -1,250,000 5
KYMR funds › Kymera Therapeutics Inc TRIM 6.8% -0.5% 336.7 2,935,830 -251,000 5
ERAS funds › Erasca Inc ADD 4.2% -0.8% 208.8 11,397,781 +153,535 5
MANE funds › Veradermics Inc ADD 4.1% +1.5% 203.5 1,655,374 +150,000 2
TNGX funds › Tango Therapeutics Inc ADD 3.9% +0.6% 193.2 6,179,364 +522,259 5
RVMD funds › Revolution Medicines Inc TRIM 3.4% +0.4% 168.6 900,000 -210,980 5
BCAX funds › Bicara Therapeutics Inc TRIM 3.4% +0.2% 166.4 5,602,970 -200,000 5
ARWR funds › Arrowhead Pharmaceuticals Inc ADD 2.8% +0.0% 139.8 1,715,476 +100,000 5
ONC funds › BeOne Medicines AG HOLD 2.7% -1.1% 132.5 465,000 +0 5
EWTX funds › Edgewise Therapeutics Inc TRIM 2.6% -1.2% 129.4 3,184,629 -1,245,634 5
RYTM funds › Rhythm Pharmaceuticals Inc ADD 2.6% +0.8% 126.2 1,136,275 +410,764 5
LXRX funds › Lexicon Pharmaceuticals Inc HOLD 2.2% +0.2% 106.3 44,303,518 +0 5
ELVN funds › Enliven Therapeutics Inc ADD 1.8% +1.0% 90.1 1,774,411 +1,028,185 2
SYRE funds › Spyre Therapeutics Inc ADD 1.7% +0.6% 86.0 968,598 +150,000 5
PBLS funds › Parabilis Medicines Inc NEW 1.7% +1.7% 81.9 2,992,259 +2,992,259 1
XENE funds › Xenon Pharmaceuticals Inc HOLD 1.6% -0.5% 79.6 1,318,564 +0 5
SLDB funds › Solid Biosciences Inc HOLD 1.6% +0.0% 76.8 7,690,405 +0 5
ABVX funds › Abivax SA NEW 1.6% +1.6% 76.8 576,000 +576,000 1
COAG funds › Hemab Therapeutics Holdings Inc NEW 1.6% +1.6% 76.6 2,086,834 +2,086,834 1
RCUS funds › Arcus Biosciences Inc TRIM 1.5% -0.3% 74.6 2,420,430 -586,647 5
COGT funds › Cogent Biosciences Inc ADD 1.5% -0.4% 72.0 1,859,279 +150,000 5
RLAY funds › Relay Therapeutics Inc NEW 1.4% +1.4% 68.3 3,650,000 +3,650,000 1
TSHA funds › Taysha Gene Therapies Inc ADD 1.4% +0.3% 67.1 9,846,579 +1,016,666 5
DFTX funds › Definium Therapeutics Inc ADD 1.4% +0.9% 66.8 1,419,493 +500,000 2
STOK funds › Stoke Therapeutics Inc HOLD 1.3% -0.5% 65.3 1,995,347 +0 5
IRON funds › Disc Medicine Inc TRIM 1.3% -0.4% 65.0 888,401 -100,000 5
CYTK funds › Cytokinetics Inc ADD 1.3% +0.2% 64.7 758,952 +145,000 2
SEPN funds › Septerna Inc TRIM 1.3% -0.0% 63.6 1,900,000 -100,000 5
OLMA funds › Olema Pharmaceuticals Inc ADD 1.2% -0.7% 60.8 4,856,949 +100,000 3
CRNX funds › Crinetics Pharmaceuticals Inc TRIM 1.1% -0.8% 53.2 1,420,788 -482,848 5
KLRA funds › Kailera Therapeutics Inc NEW 1.0% +1.0% 48.8 2,214,286 +2,214,286 1
DYN funds › Dyne Therapeutics, Inc TRIM 1.0% -0.2% 47.3 2,129,125 -100,000 5
GPCR funds › Structure Therapeutics Inc TRIM 1.0% -0.8% 46.9 872,967 -455,731 4
TBLA funds › Taboola.com Ltd TRIM 0.9% -0.0% 42.1 8,423,410 -1,546,085 5
PVLA funds › Palvella Therapeutics Inc HOLD 0.8% -0.1% 39.3 257,485 +0 3
SLN funds › Silence Therapeutics PLC ADD 0.7% +0.3% 36.4 3,311,438 +400,000 5
DNLI funds › Denali Therapeutics Inc HOLD 0.7% -0.0% 35.9 1,396,513 +0 5
RELY funds › Remitly Global Inc HOLD 0.7% +0.0% 34.6 1,543,271 +0 5
CGEM funds › Cullinan Therapeutics Inc ADD 0.7% +0.2% 34.5 1,893,410 +700,000 5
COF funds › Capital One Finl Corp NEW 0.7% +0.7% 34.4 171,615 +171,615 1
TRVI funds › Trevi Therapeutics Inc HOLD 0.7% +0.1% 33.3 1,786,867 +0 5
ORIC funds › Oric Pharmaceuticals Inc HOLD 0.7% -0.4% 32.5 2,998,192 +0 5
GOOGL funds › Alphabet Inc ADD 0.7% +0.1% 32.2 90,000 +24,297 5
DBVT funds › Dbv Technologies SA HOLD 0.6% -0.5% 30.5 1,857,362 +0 3
ABSI funds › Absci Corp ADD Common Stock 0.6% +0.4% 28.7 2,474,764 +674,764 2
SION funds › Sionna Therapeutics Inc ADD 0.5% +0.2% 26.9 610,515 +310,515 5
RAPP funds › Rapport Therapeutics Inc HOLD 0.5% -0.0% 26.7 641,469 +0 5
AMLX funds › Amylyx Pharmaceuticals Inc ADD 0.5% +0.1% 26.6 1,480,586 +250,586 2
ANNX funds › Annexon Inc ADD 0.5% -0.1% 25.5 4,458,646 +500,000 2
MNPR funds › Monopar Therapeutics Inc HOLD 0.5% +0.1% 25.0 270,118 +0 3
ORKA funds › Oruka Therapeutics Inc NEW 0.5% +0.5% 23.8 250,000 +250,000 1
SPTX funds › Seaport Therapeutics Inc NEW 0.5% +0.5% 23.8 1,095,316 +1,095,316 1
DMRA funds › Damora Therapeutics Inc HOLD 0.5% -0.2% 23.4 900,000 +0 2
TYRA funds › Tyra Biosciences Inc NEW 0.5% +0.5% 23.2 725,000 +725,000 1
ZURA funds › Zura Bio Ltd HOLD 0.4% -0.2% 22.0 3,734,866 +0 3
TSM funds › Taiwan Semiconductor Manufacturing Co Ltd ADD 0.4% +0.0% 21.3 44,700 +2,500 5
NVDA funds › NVIDIA Corp ADD 0.4% -0.0% 19.0 95,000 +5,915 5
RZLT funds › Rezolute Inc HOLD 0.4% +0.1% 17.3 3,328,287 +0 2
MPLT funds › MapLight Therapeutics Inc HOLD 0.3% +0.1% 16.1 450,000 +0 3
NMRA funds › Neumora Therapeutics Inc HOLD 0.3% -0.2% 14.4 8,497,822 +0 5
NBIS funds › Nebius Group NV TRIM 0.3% -0.0% 14.4 52,000 -61,614 5
MSFT funds › Microsoft Corp TRIM 0.3% -0.1% 14.0 37,500 -3,880 5
CTMX funds › CytomX Therapeutics Inc HOLD 0.3% -0.2% 13.0 3,457,711 +0 2
GENB funds › Generate Biomedicines Inc HOLD 0.3% -0.0% 12.4 736,104 +0 2
IKT funds › Inhibikase Therapeutics Inc HOLD 0.2% -0.0% 11.9 5,850,000 +0 3
ADAG funds › Adagene Inc NEW 0.2% +0.2% 11.2 2,666,666 +2,666,666 1
ENGN funds › enGene Therapeutics Inc NEW 0.2% +0.2% 10.8 6,256,662 +6,256,662 1
WHWK funds › Whitehawk Therapeutics Inc ADD Common Stock 0.2% +0.0% 10.7 2,337,102 +255,102 5
DDOG funds › Datadog Inc TRIM 0.2% +0.0% 10.4 40,000 -14,300 5
NOW funds › ServiceNow Inc ADD 0.2% -0.1% 9.9 100,000 +12,910 5
AVGO funds › Broadcom Inc ADD 0.2% +0.1% 9.4 25,000 +10,000 3
IONQ funds › IONQ Inc HOLD 0.2% +0.0% 9.1 170,000 +0 5
FROG funds › Jfrog Ltd TRIM 0.2% +0.0% 8.7 95,500 -33,316 5
OCS funds › Oculis Holding AG NEW 0.2% +0.2% 8.7 625,000 +625,000 1
IREN funds › IREN Ltd ADD 0.2% +0.1% 8.0 175,000 +131,900 4
AMZN funds › Amazon.com Inc TRIM 0.2% -0.1% 7.7 32,500 -14,141 5
CRWD funds › CrowdStrike Holdings Inc TRIM 0.2% -0.1% 7.6 10,000 -13,070 5
DSGN funds › Design Therapeutics Inc NEW 0.2% +0.2% 7.6 523,212 +523,212 1
PDD funds › PDD Holdings Inc ADD 0.1% -0.1% 7.2 95,000 +11,599 5
MSLE funds › Satellos Bioscience Inc HOLD 0.1% +0.0% 6.9 892,074 +0 2
DT funds › Dynatrace, Inc ADD 0.1% -0.0% 6.8 155,000 +5,000 5
TENX funds › Tenax Therapeutics Inc HOLD 0.1% -0.1% 6.2 427,141 +0 4
VTVT funds › vTv Therapeutics Inc HOLD 0.1% -0.1% 6.1 163,000 +0 4
ELOX funds › Eloxx Pharmaceuticals Inc NEW 0.1% +0.1% 5.6 400,000 +400,000 1
AGMB funds › Agomab Therapeutics NV HOLD 0.1% -0.0% 5.3 411,250 +0 2
BABA funds › Alibaba Group Holding Ltd NEW 0.1% +0.1% 4.8 50,000 +50,000 1
KRRO funds › Korro Bio Inc HOLD 0.1% -0.0% 4.6 347,718 +0 5
CLBT funds › Cellebrite DI Ltd HOLD 0.1% -0.0% 4.5 311,544 +0 5
IVVD funds › Invivyd Inc ADD 0.1% -0.1% 4.4 5,000,000 +1,000,000 3
OUST funds › Ouster Inc NEW 0.1% +0.1% 4.2 67,500 +67,500 1
PALI funds › Palisade Bio Inc NEW 0.1% +0.1% 4.2 2,000,000 +2,000,000 1
AEVA funds › Aeva Technologies Inc ADD 0.1% +0.0% 4.2 145,459 +35,459 2
SEER funds › Seer Inc HOLD 0.1% -0.0% 4.1 2,458,673 +0 5
NBP funds › NovaBridge Biosciences TRIM 0.1% -0.1% 3.9 2,004,739 -995,261 4
GTLB funds › GitLab Inc ADD 0.1% +0.0% 3.8 125,000 +25,000 5
ODTX funds › Odyssey Therapeutics Inc NEW 0.1% +0.1% 3.7 200,000 +200,000 1
FHTX funds › Foghorn Therapeutics Inc HOLD 0.1% -0.0% 3.5 720,720 +0 5
AGEN funds › Agenus Inc HOLD 0.1% -0.0% 3.3 1,064,250 +0 5
MNDY funds › monday.com Ltd ADD 0.1% +0.0% 3.1 42,500 +17,500 4
ZTS funds › Zoetis Inc NEW 0.1% +0.1% 2.5 35,000 +35,000 1
WK funds › Workiva Inc TRIM 0.0% -0.1% 2.2 45,000 -47,500 5
NFLX funds › Netflix Inc NEW 0.0% +0.0% 1.8 25,000 +25,000 1
KLRS funds › Kalaris Therapeutics Inc HOLD 0.0% -0.0% 1.8 435,798 +0 5
QNT funds › Quantinuum Inc NEW 0.0% +0.0% 1.6 20,000 +20,000 1
RANI funds › Rani Therapeutics Holdings Inc HOLD 0.0% -0.0% 1.5 2,000,000 +0 3
TSLA funds › Tesla Inc TRIM 0.0% -0.2% 1.5 3,500 -18,000 5
BEKE funds › KE Holdings Inc HOLD 0.0% -0.0% 1.5 100,000 +0 5
ENTX funds › Entera Bio Ltd NEW 0.0% +0.0% 1.3 736,457 +736,457 1
MDLN funds › Medline Inc HOLD 0.0% -0.0% 1.0 25,000 +0 3
LITE funds › Lumentum Holdings Inc NEW 0.0% +0.0% 0.9 1,055 +1,055 1
FIG funds › Figma Inc HOLD 0.0% -0.0% 0.9 50,000 +0 4
GOSS funds › Gossamer Bio Inc HOLD 0.0% -0.0% 0.9 5,208,968 +0 5
FOXA funds › Fox Corp NEW 0.0% +0.0% 0.5 10,000 +10,000 1
T funds › AT&T Inc NEW 0.0% +0.0% 0.5 25,000 +25,000 1
NU funds › Nu Holdings Ltd. HOLD 0.0% -0.0% 0.3 25,000 +0 2
MU funds › Micron Technology Inc EXIT 0.0% -0.1% 0.0 0 -6,000 0
QURE funds › Uniqure NV EXIT 0.0% -0.5% 0.0 0 -1,000,000 0
AS funds › Amer Sports Inc EXIT 0.0% -0.0% 0.0 0 -50,000 0
FULC funds › Fulcrum Therapeutics Inc EXIT 0.0% -0.5% 0.0 0 -2,350,000 0
CUSIP:29286M105 funds › enGene Holdings Inc EXIT 0.0% -1.0% 0.0 0 -5,253,159 0
PRMB funds › Primo Brands Corp EXIT 0.0% -0.0% 0.0 0 -50,000 0
CUSIP:152309100 funds › Centessa Pharmaceuticals PLC EXIT 0.0% -1.2% 0.0 0 -1,053,464 0
FPS funds › Forgent Power Solutions, Inc EXIT 0.0% -0.1% 0.0 0 -100,000 0
BCYC funds › Bicycle Therapeutics PLC EXIT 0.0% -0.2% 0.0 0 -1,560,882 0
WVE funds › WAVE Life Sciences Ltd EXIT 0.0% -0.5% 0.0 0 -2,450,000 0

Point-in-time history

Each row is this fund as of that period, not as of today — what the scoring for that quarter actually saw.
PeriodAUM ($M)Positions TurnoverTop-10 wtHerfindahl Quality Q Skill Universe
2026Q2 4,926 115 0.20 45% 0.032 0.590 in
2026Q1 3,607 100 0.22 50% 0.043 0.569 in
2025Q4 3,352 113 0.20 46% 0.041 0.509 in
2025Q3 2,556 115 0.18 47% 0.041 0.530 in
2025Q2 1,932 110 0.16 48% 0.049 0.575 entered
2025Q1 1,756 116 0.00 51% 0.049 0.000 out
Long US-equity 13F disclosures only · up to 45-day reporting lag · sells = reduce/avoid, not short. JSON: /api/signals · /api/funds · /api/status