Insider
| Ticker | Insider | Role | Type | Date | Shares | Price | Value | Notes | Filing |
|---|---|---|---|---|---|---|---|---|---|
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Award | 2026-09-19 | 107 | — | — | Acquired | EDGAR |
| ALNY | PYOTT DAVID E I | Director | Sale | 2026-06-01 | 1,222 | $299.87 | $366,441 | Disposed | EDGAR |
| ALNY | PYOTT DAVID E I | Director | Sale | 2026-06-01 | 1,175 | $298.91 | $351,219 | Disposed | EDGAR |
| ALNY | PYOTT DAVID E I | Director | Option exercise | 2026-06-01 | 3,830 | — | — | Acquired | EDGAR |
| ALNY | PYOTT DAVID E I | Director | Sale | 2026-06-01 | 921 | $297.71 | $274,191 | Disposed | EDGAR |
| ALNY | PYOTT DAVID E I | Director | Sale | 2026-06-01 | 17 | $302.65 | $5,145 | Disposed | EDGAR |
| ALNY | PYOTT DAVID E I | Director | Sale | 2026-06-01 | 495 | $300.72 | $148,856 | Disposed | EDGAR |
| ALNY | Sigal Charles Elliott | Director | Award | 2026-05-20 | 671 | — | — | Acquired | EDGAR |
| ALNY | Reitan Colleen F | Director | Award | 2026-05-20 | 671 | — | — | Acquired | EDGAR |
| ALNY | Arbuckle Stuart A | Director | Award | 2026-05-20 | 671 | — | — | Acquired | EDGAR |
| ALNY | PYOTT DAVID E I | Director | Award | 2026-05-20 | 671 | — | — | Acquired | EDGAR |
| ALNY | Ausiello Dennis A | Director | Award | 2026-05-20 | 671 | — | — | Acquired | EDGAR |
| ALNY | BRANDICOURT OLIVIER | Director | Award | 2026-05-20 | 671 | — | — | Acquired | EDGAR |
| ALNY | SCHULMAN AMY W | Director | Award | 2026-05-20 | 838 | — | — | Acquired | EDGAR |
| ALNY | HAMBURG MARGARET A | Director | Award | 2026-05-20 | 671 | — | — | Acquired | EDGAR |
| ALNY | KELLOGG PETER N | Director | Award | 2026-05-20 | 671 | — | — | Acquired | EDGAR |
| ALNY | SCHULMAN AMY W | Director | Option exercise | 2026-05-13 | 11,250 | $70.20 | $789,750 | Acquired | EDGAR |
| ALNY | McLaughlin Melissa | Chief Human Resources Officer | Sale | 2026-04-06 | 56 | $320.14 | $17,928 | Disposed | EDGAR |
| ALNY | McLaughlin Melissa | Chief Human Resources Officer | Sale | 2026-04-06 | 909 | $329.76 | $299,752 | Disposed | EDGAR |
| ALNY | McLaughlin Melissa | Chief Human Resources Officer | Sale | 2026-04-06 | 829 | $330.46 | $273,951 | Disposed | EDGAR |
| ALNY | McLaughlin Melissa | Chief Human Resources Officer | Sale | 2026-04-06 | 293 | $331.89 | $97,244 | Disposed | EDGAR |
| ALNY | McLaughlin Melissa | Chief Human Resources Officer | Sale | 2026-04-06 | 199 | $333.94 | $66,454 | Disposed | EDGAR |
| ALNY | McLaughlin Melissa | Chief Human Resources Officer | Sale | 2026-04-02 | 209 | $318.47 | $66,560 | Disposed | EDGAR |
| ALNY | McLaughlin Melissa | Chief Human Resources Officer | Sale | 2026-04-02 | 359 | $317.44 | $113,961 | Disposed | EDGAR |
| ALNY | McLaughlin Melissa | Chief Human Resources Officer | Sale | 2026-04-02 | 265 | $316.61 | $83,902 | Disposed | EDGAR |
| ALNY | McLaughlin Melissa | Chief Human Resources Officer | Sale | 2026-04-02 | 8 | $325.49 | $2,604 | Disposed | EDGAR |
| ALNY | McLaughlin Melissa | Chief Human Resources Officer | Sale | 2026-04-02 | 147 | $320.62 | $47,131 | Disposed | EDGAR |
| ALNY | McLaughlin Melissa | Chief Human Resources Officer | Sale | 2026-04-02 | 224 | $321.64 | $72,047 | Disposed | EDGAR |
| ALNY | McLaughlin Melissa | Chief Human Resources Officer | Sale | 2026-04-02 | 245 | $322.86 | $79,101 | Disposed | EDGAR |
| ALNY | McLaughlin Melissa | Chief Human Resources Officer | Sale | 2026-04-02 | 81 | $323.64 | $26,215 | Disposed | EDGAR |
| ALNY | McLaughlin Melissa | Chief Human Resources Officer | Sale | 2026-04-02 | 86 | $319.69 | $27,493 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-03-05 | 510 | $324.59 | $165,541 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-03-05 | 740 | $323.55 | $239,427 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-03-05 | 148 | $324.60 | $48,041 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-03-05 | 233 | $323.25 | $75,317 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-03-05 | 124 | $321.81 | $39,904 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-03-05 | 654 | $322.33 | $210,804 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-03-05 | 153 | $326.24 | $49,915 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-03-05 | 500 | $326.08 | $163,040 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-03-04 | 102 | $320.01 | $32,641 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-03-04 | 29 | $319.03 | $9,252 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-03-04 | 28 | $320.01 | $8,960 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-03-04 | 59 | $320.81 | $18,928 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-03-04 | 79 | $321.82 | $25,424 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-03-04 | 106 | $319.03 | $33,817 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-03-04 | 215 | $320.81 | $68,974 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-03-04 | 289 | $321.82 | $93,006 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-03-04 | 350 | $323.01 | $113,054 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-03-04 | 767 | $323.84 | $248,385 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-03-04 | 272 | $324.88 | $88,367 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-03-04 | 208 | $325.67 | $67,739 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-03-04 | 135 | $319.03 | $43,069 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-03-04 | 129 | $320.01 | $41,281 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-03-04 | 274 | $320.81 | $87,902 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-03-04 | 368 | $321.82 | $118,430 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-03-04 | 444 | $323.01 | $143,416 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-03-04 | 973 | $323.84 | $315,096 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-03-04 | 345 | $324.88 | $112,084 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-03-04 | 265 | $325.67 | $86,303 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-03-04 | 309 | $321.82 | $99,442 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-03-04 | 374 | $323.01 | $120,806 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-03-04 | 818 | $323.84 | $264,901 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-03-04 | 291 | $324.88 | $94,540 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-03-04 | 223 | $325.67 | $72,624 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-03-04 | 102 | $320.01 | $32,641 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-03-04 | 215 | $320.81 | $68,974 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-03-04 | 289 | $321.82 | $93,006 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-03-04 | 350 | $323.01 | $113,054 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-03-04 | 767 | $323.84 | $248,385 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-03-04 | 272 | $324.88 | $88,367 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-03-04 | 208 | $325.67 | $67,739 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-03-04 | 96 | $323.01 | $31,009 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-03-04 | 210 | $323.84 | $68,006 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-03-04 | 75 | $324.88 | $24,366 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-03-04 | 57 | $325.67 | $18,563 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-03-04 | 114 | $319.03 | $36,369 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-03-04 | 109 | $320.01 | $34,881 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-03-04 | 230 | $320.81 | $73,786 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-03-04 | 106 | $319.03 | $33,817 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-03-03 | 359 | $321.58 | $115,447 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-03-03 | 463 | $321.50 | $148,854 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-03-03 | 289 | $316.55 | $91,483 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-03-03 | 640 | $320.48 | $205,107 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-03-03 | 317 | $319.06 | $101,142 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-03-03 | 282 | $318.62 | $89,851 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-03-03 | 722 | $320.51 | $231,408 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-03-03 | 355 | $316.74 | $112,443 | Disposed | EDGAR |
| ALNY | SUPRAN BRYAN | EVP, CLO and Secretary | Award | 2026-03-02 | 1,539 | — | — | Acquired | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-03-02 | 454 | $327.67 | $148,762 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-03-02 | 129 | $331.93 | $42,819 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-03-02 | 112 | $330.85 | $37,055 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-03-02 | 234 | $329.71 | $77,152 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-03-02 | 138 | $328.71 | $45,362 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-03-02 | 541 | $326.81 | $176,804 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-03-02 | 356 | $325.63 | $115,924 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Award | 2026-03-02 | 4,769 | — | — | Acquired | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-03-02 | 1,098 | $325.63 | $357,542 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-03-02 | 382 | $324.65 | $124,016 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-03-02 | 200 | $323.62 | $64,724 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Award | 2026-03-02 | 13,844 | — | — | Acquired | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Award | 2026-03-02 | 4,769 | — | — | Acquired | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-03-02 | 47 | $323.62 | $15,210 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-03-02 | 90 | $324.65 | $29,218 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-03-02 | 258 | $325.63 | $84,013 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-03-02 | 392 | $326.81 | $128,110 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-03-02 | 329 | $327.67 | $107,803 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-03-02 | 100 | $328.71 | $32,871 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-03-02 | 170 | $329.71 | $56,051 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-03-02 | 81 | $330.85 | $26,799 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-03-02 | 94 | $331.93 | $31,201 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-03-02 | 37 | $332.64 | $12,308 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-03-02 | 53 | $332.64 | $17,630 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Award | 2026-03-02 | 3,688 | — | — | Acquired | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-03-02 | 47 | $323.62 | $15,210 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-03-02 | 90 | $324.65 | $29,218 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-03-02 | 258 | $325.63 | $84,013 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-03-02 | 392 | $326.81 | $128,110 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-03-02 | 329 | $327.67 | $107,803 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-03-02 | 100 | $328.71 | $32,871 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-03-02 | 170 | $329.71 | $56,051 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-03-02 | 81 | $330.85 | $26,799 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-03-02 | 94 | $331.93 | $31,201 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-03-02 | 37 | $332.64 | $12,308 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-03-02 | 124 | $324.65 | $40,257 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-03-02 | 101 | $331.93 | $33,525 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-03-02 | 42 | $332.64 | $13,971 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-03-02 | 97 | $324.65 | $31,491 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-03-02 | 421 | $326.81 | $137,587 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-03-02 | 353 | $327.67 | $115,668 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-03-02 | 50 | $323.62 | $16,181 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Award | 2026-03-02 | 4,769 | — | — | Acquired | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-03-02 | 107 | $328.71 | $35,172 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-03-02 | 182 | $329.71 | $60,007 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-03-02 | 87 | $330.85 | $28,784 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-03-02 | 1,399 | $327.67 | $458,410 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-03-02 | 1,669 | $326.81 | $545,446 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-03-02 | 65 | $323.62 | $21,035 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-03-02 | 277 | $325.63 | $90,200 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-03-02 | 424 | $328.71 | $139,373 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-03-02 | 722 | $329.71 | $238,051 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-03-02 | 346 | $330.85 | $114,474 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-03-02 | 399 | $331.93 | $132,440 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-03-02 | 160 | $332.64 | $53,222 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Option exercise | 2026-02-27 | 1,666 | — | — | Acquired | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-02-27 | 1,159 | $331.49 | $384,197 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Option exercise | 2026-02-27 | 1,908 | — | — | Acquired | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-02-27 | 942 | $332.48 | $313,196 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-02-27 | 140 | $334.39 | $46,815 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-02-27 | 127 | $328.92 | $41,773 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-02-27 | 2,259 | $330.73 | $747,119 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Option exercise | 2026-02-27 | 5,921 | — | — | Acquired | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Option exercise | 2026-02-27 | 1,908 | — | — | Acquired | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Award | 2026-02-23 | 158 | — | — | Acquired | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-02-17 | 2,041 | $331.96 | $677,532 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-02-13 | 2,242 | $310.08 | $695,201 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-02-13 | 1,959 | $310.08 | $607,448 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-02-13 | 6,958 | $310.08 | $2,157,542 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-02-13 | 2,242 | $310.08 | $695,201 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-02-13 | 1,959 | $310.08 | $607,448 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Award | 2026-02-12 | 4,000 | — | — | Acquired | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Award | 2026-02-12 | 4,000 | — | — | Acquired | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Award | 2026-02-12 | 4,579 | — | — | Acquired | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Award | 2026-02-12 | 14,209 | — | — | Acquired | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Award | 2026-02-12 | 4,579 | — | — | Acquired | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-01-13 | 280 | $372.93 | $104,420 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-01-13 | 644 | $370.00 | $238,280 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-01-13 | 122 | $374.33 | $45,668 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-01-13 | 485 | $371.24 | $180,051 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-01-13 | 197 | $367.52 | $72,401 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-01-13 | 562 | $368.76 | $207,243 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-01-12 | 96 | $357.17 | $34,288 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-01-12 | 39 | $353.95 | $13,804 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-01-12 | 42 | $355.16 | $14,917 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-01-12 | 118 | $370.87 | $43,763 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-01-12 | 21 | $372.46 | $7,822 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-01-12 | 88 | $374.44 | $32,951 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-01-12 | 247 | $353.95 | $87,426 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-01-12 | 269 | $355.16 | $95,538 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-01-12 | 263 | $356.09 | $93,652 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-01-12 | 607 | $357.17 | $216,802 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-01-12 | 778 | $358.18 | $278,664 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-01-12 | 537 | $359.14 | $192,858 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-01-12 | 980 | $360.22 | $353,016 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-01-12 | 624 | $361.45 | $225,545 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-01-12 | 464 | $362.38 | $168,144 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-01-12 | 301 | $363.55 | $109,429 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-01-12 | 1,259 | $364.83 | $459,321 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-01-12 | 1,395 | $365.56 | $509,956 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-01-12 | 316 | $366.41 | $115,786 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-01-12 | 261 | $367.40 | $95,891 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-01-12 | 584 | $368.62 | $215,274 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-01-12 | 253 | $369.48 | $93,478 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2026-01-12 | 94 | $377.82 | $35,515 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-01-12 | 72 | $353.95 | $25,484 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-01-12 | 78 | $355.16 | $27,702 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-01-12 | 76 | $356.09 | $27,063 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-01-12 | 176 | $357.17 | $62,862 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-01-12 | 226 | $358.18 | $80,949 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-01-12 | 156 | $359.14 | $56,026 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-01-12 | 284 | $360.22 | $102,302 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-01-12 | 181 | $361.45 | $65,422 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-01-12 | 135 | $362.38 | $48,921 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-01-12 | 87 | $363.55 | $31,629 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-01-12 | 365 | $364.83 | $133,163 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-01-12 | 405 | $365.56 | $148,052 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-01-12 | 92 | $366.41 | $33,710 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-01-12 | 170 | $368.62 | $62,665 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-01-12 | 73 | $369.48 | $26,972 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-01-12 | 36 | $370.87 | $13,351 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-01-12 | 6 | $372.46 | $2,235 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-01-12 | 25 | $374.44 | $9,361 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-01-12 | 27 | $377.82 | $10,201 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-01-12 | 39 | $353.95 | $13,804 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-01-12 | 42 | $355.16 | $14,917 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-01-12 | 41 | $356.09 | $14,600 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-01-12 | 96 | $357.17 | $34,288 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-01-12 | 123 | $358.18 | $44,056 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-01-12 | 85 | $359.14 | $30,527 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-01-12 | 155 | $360.22 | $55,834 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-01-12 | 98 | $361.45 | $35,422 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-01-12 | 73 | $362.38 | $26,454 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-01-12 | 47 | $363.55 | $17,087 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-01-12 | 199 | $364.83 | $72,601 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-01-12 | 220 | $365.56 | $80,423 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-01-12 | 50 | $366.41 | $18,320 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-01-12 | 92 | $368.62 | $33,913 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-01-12 | 40 | $369.48 | $14,779 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-01-12 | 19 | $370.87 | $7,047 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-01-12 | 2 | $372.46 | $745 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-01-12 | 14 | $374.44 | $5,242 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2026-01-12 | 15 | $377.82 | $5,667 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-01-12 | 39 | $353.95 | $13,804 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-01-12 | 42 | $355.16 | $14,917 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-01-12 | 41 | $356.09 | $14,600 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-01-12 | 96 | $357.17 | $34,288 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-01-12 | 123 | $358.18 | $44,056 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-01-12 | 85 | $359.14 | $30,527 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-01-12 | 155 | $360.22 | $55,834 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-01-12 | 98 | $361.45 | $35,422 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-01-12 | 73 | $362.38 | $26,454 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-01-12 | 47 | $363.55 | $17,087 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-01-12 | 199 | $364.83 | $72,601 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-01-12 | 220 | $365.56 | $80,423 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-01-12 | 50 | $366.41 | $18,320 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-01-12 | 92 | $368.62 | $33,913 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-01-12 | 40 | $369.48 | $14,779 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-01-12 | 19 | $370.87 | $7,047 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-01-12 | 2 | $372.46 | $745 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-01-12 | 14 | $374.44 | $5,242 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2026-01-12 | 15 | $377.82 | $5,667 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2026-01-12 | 34 | $375.65 | $12,772 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-01-12 | 41 | $356.09 | $14,600 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-01-12 | 123 | $358.18 | $44,056 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-01-12 | 85 | $359.14 | $30,527 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-01-12 | 155 | $360.22 | $55,834 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-01-12 | 98 | $361.45 | $35,422 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-01-12 | 73 | $362.38 | $26,454 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-01-12 | 47 | $363.55 | $17,087 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-01-12 | 199 | $364.83 | $72,601 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-01-12 | 220 | $365.56 | $80,423 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-01-12 | 50 | $366.41 | $18,320 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-01-12 | 92 | $368.62 | $33,913 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-01-12 | 40 | $369.48 | $14,779 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-01-12 | 18 | $370.87 | $6,676 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-01-12 | 3 | $372.46 | $1,117 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-01-12 | 14 | $374.44 | $5,242 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-01-12 | 19 | $375.65 | $7,137 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2026-01-12 | 15 | $377.82 | $5,667 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Award | 2026-01-11 | 6,193 | — | — | Acquired | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Award | 2026-01-11 | 3,800 | — | — | Acquired | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Award | 2026-01-11 | 19,003 | — | — | Acquired | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Award | 2026-01-11 | 3,800 | — | — | Acquired | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Award | 2026-01-11 | 3,800 | — | — | Acquired | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Option exercise | 2025-11-26 | 2,352 | $85.00 | $199,920 | Acquired | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Option exercise | 2025-11-26 | 847 | $118.05 | $99,988 | Acquired | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Option exercise | 2025-11-26 | 659 | $151.59 | $99,898 | Acquired | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Option exercise | 2025-11-26 | 839 | $119.13 | $99,950 | Acquired | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Tax withholding | 2025-11-26 | 1,121 | $445.12 | $498,980 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-11-17 | 295 | $463.08 | $136,609 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-11-17 | 129 | $451.51 | $58,245 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-11-17 | 368 | $455.24 | $167,528 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Option exercise | 2025-11-17 | 8,161 | $119.13 | $972,220 | Acquired | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-11-17 | 8,168 | $449.00 | $3,667,432 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-11-17 | 96 | $450.09 | $43,209 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-11-17 | 364 | $456.25 | $166,075 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-11-17 | 262 | $457.39 | $119,836 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-11-17 | 794 | $458.41 | $363,978 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-11-17 | 622 | $459.89 | $286,052 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-11-17 | 707 | $460.84 | $325,814 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-11-17 | 323 | $461.96 | $149,213 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-11-13 | 881 | $453.99 | $399,965 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-11-13 | 1,702 | $451.94 | $769,202 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-11-13 | 2,218 | $450.69 | $999,630 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-11-13 | 1,477 | $450.02 | $664,680 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-11-13 | 1,013 | $448.76 | $454,594 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Option exercise | 2025-11-13 | 10,000 | $119.13 | $1,191,300 | Acquired | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-11-13 | 654 | $447.73 | $292,815 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-11-13 | 261 | $456.03 | $119,024 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-11-13 | 195 | $454.69 | $88,665 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-11-13 | 1,599 | $452.85 | $724,107 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-11-12 | 3,406 | $455.56 | $1,551,637 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-11-12 | 711 | $448.07 | $318,578 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-11-12 | 453 | $450.17 | $203,927 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-11-12 | 2,132 | $449.15 | $957,588 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-11-12 | 1,960 | $454.84 | $891,486 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-11-12 | 604 | $457.71 | $276,457 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-11-12 | 1,069 | $453.52 | $484,813 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-11-12 | 430 | $458.42 | $197,121 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Option exercise | 2025-11-12 | 650 | $42.22 | $27,443 | Acquired | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-11-12 | 2,420 | $456.64 | $1,105,069 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-11-12 | 1,210 | $452.43 | $547,440 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Option exercise | 2025-11-12 | 15,000 | $119.13 | $1,786,950 | Acquired | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-11-12 | 1,255 | $451.16 | $566,206 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2025-10-03 | 215 | $454.37 | $97,690 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2025-10-03 | 417 | $453.51 | $189,114 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2025-10-03 | 898 | $451.76 | $405,680 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2025-10-03 | 682 | $449.99 | $306,893 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2025-10-03 | 810 | $450.63 | $365,010 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-10-02 | 159 | $451.86 | $71,846 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2025-10-02 | 115 | $446.53 | $51,351 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2025-10-02 | 56 | $447.92 | $25,084 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2025-10-02 | 180 | $448.77 | $80,779 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-10-02 | 150 | $446.53 | $66,980 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-10-02 | 73 | $447.92 | $32,698 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-10-02 | 234 | $448.77 | $105,012 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-10-02 | 324 | $449.79 | $145,732 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-10-02 | 704 | $450.81 | $317,370 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-10-02 | 432 | $451.86 | $195,204 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-10-02 | 869 | $452.69 | $393,388 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-10-02 | 428 | $453.77 | $194,214 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-10-02 | 317 | $454.84 | $144,184 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-10-02 | 95 | $455.82 | $43,303 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-10-02 | 191 | $457.43 | $87,369 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-10-02 | 4 | $457.64 | $1,831 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-10-02 | 350 | $446.53 | $156,286 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-10-02 | 171 | $447.92 | $76,594 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-10-02 | 548 | $448.77 | $245,926 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-10-02 | 758 | $449.79 | $340,941 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-10-02 | 1,642 | $450.81 | $740,230 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-10-02 | 1,010 | $451.86 | $456,379 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-10-02 | 2,029 | $452.69 | $918,508 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-10-02 | 999 | $453.77 | $453,316 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-10-02 | 741 | $454.84 | $337,036 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-10-02 | 221 | $455.82 | $100,736 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-10-02 | 446 | $457.43 | $204,014 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-10-02 | 9 | $457.64 | $4,119 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-10-02 | 55 | $446.53 | $24,559 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-10-02 | 27 | $447.92 | $12,094 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-10-02 | 86 | $448.77 | $38,594 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-10-02 | 119 | $449.79 | $53,525 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-10-02 | 260 | $450.81 | $117,211 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-10-02 | 319 | $452.69 | $144,408 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-10-02 | 157 | $453.77 | $71,242 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-10-02 | 117 | $454.84 | $53,216 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-10-02 | 35 | $455.82 | $15,954 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-10-02 | 70 | $457.43 | $32,020 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-10-02 | 1 | $457.64 | $458 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-10-02 | 96 | $446.53 | $42,867 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-10-02 | 47 | $447.92 | $21,052 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-10-02 | 150 | $448.77 | $67,316 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-10-02 | 207 | $449.79 | $93,107 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-10-02 | 449 | $450.81 | $202,414 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-10-02 | 276 | $451.86 | $124,713 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-10-02 | 555 | $452.69 | $251,243 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-10-02 | 273 | $453.77 | $123,879 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-10-02 | 203 | $454.84 | $92,333 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-10-02 | 60 | $455.82 | $27,349 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-10-02 | 122 | $457.43 | $55,806 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-10-02 | 3 | $457.64 | $1,373 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2025-10-02 | 249 | $449.79 | $111,998 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2025-10-02 | 541 | $450.81 | $243,888 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2025-10-02 | 332 | $451.86 | $150,018 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2025-10-02 | 668 | $452.69 | $302,397 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2025-10-02 | 329 | $453.77 | $149,290 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2025-10-02 | 244 | $454.84 | $110,981 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2025-10-02 | 73 | $455.82 | $33,275 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2025-10-02 | 147 | $457.43 | $67,242 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2025-10-02 | 3 | $457.64 | $1,373 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Award | 2025-10-01 | 2,851 | — | — | Acquired | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Award | 2025-10-01 | 3,108 | — | — | Acquired | EDGAR |
| ALNY | SUPRAN BRYAN | EVP, CLO and Secretary | Award | 2025-10-01 | 13,026 | — | — | Acquired | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Award | 2025-10-01 | 2,851 | — | — | Acquired | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Award | 2025-10-01 | 3,860 | — | — | Acquired | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Award | 2025-10-01 | 14,252 | — | — | Acquired | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Award | 2025-10-01 | 4,644 | — | — | Acquired | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Award | 2025-10-01 | 3,108 | — | — | Acquired | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Award | 2025-10-01 | 2,102 | — | — | Acquired | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Award | 2025-10-01 | 2,851 | — | — | Acquired | EDGAR |
| ALNY | Reitan Colleen F | Director | Sale | 2025-09-09 | 838 | $474.22 | $397,396 | Disposed | EDGAR |
| ALNY | Reitan Colleen F | Director | Sale | 2025-09-09 | 1,403 | $459.73 | $645,001 | Disposed | EDGAR |
| ALNY | Reitan Colleen F | Director | Sale | 2025-09-09 | 1,645 | $457.44 | $752,489 | Disposed | EDGAR |
| ALNY | Reitan Colleen F | Director | Option exercise | 2025-09-09 | 18,000 | $100.65 | $1,811,700 | Acquired | EDGAR |
| ALNY | Reitan Colleen F | Director | Sale | 2025-09-09 | 1,888 | $458.86 | $866,328 | Disposed | EDGAR |
| ALNY | Reitan Colleen F | Director | Sale | 2025-09-09 | 823 | $472.82 | $389,131 | Disposed | EDGAR |
| ALNY | Reitan Colleen F | Director | Sale | 2025-09-09 | 222 | $471.25 | $104,618 | Disposed | EDGAR |
| ALNY | Reitan Colleen F | Director | Sale | 2025-09-09 | 799 | $464.36 | $371,024 | Disposed | EDGAR |
| ALNY | Reitan Colleen F | Director | Sale | 2025-09-09 | 1,652 | $463.00 | $764,876 | Disposed | EDGAR |
| ALNY | Reitan Colleen F | Director | Sale | 2025-09-09 | 2,290 | $461.92 | $1,057,797 | Disposed | EDGAR |
| ALNY | Reitan Colleen F | Director | Sale | 2025-09-09 | 473 | $460.71 | $217,916 | Disposed | EDGAR |
| ALNY | Reitan Colleen F | Director | Sale | 2025-09-09 | 1,183 | $477.47 | $564,847 | Disposed | EDGAR |
| ALNY | Reitan Colleen F | Director | Sale | 2025-09-09 | 972 | $476.31 | $462,973 | Disposed | EDGAR |
| ALNY | Reitan Colleen F | Director | Sale | 2025-09-09 | 951 | $474.85 | $451,582 | Disposed | EDGAR |
| ALNY | Reitan Colleen F | Director | Sale | 2025-09-09 | 25 | $480.98 | $12,024 | Disposed | EDGAR |
| ALNY | Reitan Colleen F | Director | Sale | 2025-09-09 | 1,386 | $479.55 | $664,656 | Disposed | EDGAR |
| ALNY | Reitan Colleen F | Director | Sale | 2025-09-09 | 1,450 | $478.67 | $694,072 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-08-29 | 1,289 | $448.05 | $577,536 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-08-29 | 195 | $445.53 | $86,878 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-08-29 | 899 | $446.98 | $401,835 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-08-29 | 144 | $452.49 | $65,159 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-08-29 | 266 | $451.52 | $120,104 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-08-29 | 681 | $449.54 | $306,137 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2025-08-19 | 276 | $455.41 | $125,693 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2025-08-19 | 260 | $459.59 | $119,493 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2025-08-19 | 231 | $458.27 | $105,860 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2025-08-19 | 338 | $457.26 | $154,554 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2025-08-19 | 45 | $461.74 | $20,778 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2025-08-19 | 305 | $461.01 | $140,608 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-08-18 | 543 | $454.04 | $246,544 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-08-18 | 39 | $447.98 | $17,471 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2025-08-18 | 12 | $455.82 | $5,470 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2025-08-18 | 241 | $454.84 | $109,616 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2025-08-18 | 543 | $454.04 | $246,544 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2025-08-18 | 329 | $452.96 | $149,024 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2025-08-18 | 103 | $451.99 | $46,555 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2025-08-18 | 90 | $449.92 | $40,493 | Disposed | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Sale | 2025-08-18 | 39 | $447.98 | $17,471 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-08-18 | 90 | $449.92 | $40,493 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-08-18 | 39 | $447.98 | $17,471 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-08-18 | 90 | $449.92 | $40,493 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-08-18 | 103 | $451.99 | $46,555 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-08-18 | 329 | $452.96 | $149,024 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-08-18 | 103 | $451.99 | $46,555 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-08-18 | 329 | $452.96 | $149,024 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-08-18 | 543 | $454.04 | $246,544 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-08-18 | 241 | $454.84 | $109,616 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-08-18 | 12 | $455.82 | $5,470 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-08-18 | 63 | $447.98 | $28,223 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-08-18 | 147 | $449.92 | $66,138 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-08-18 | 168 | $451.99 | $75,934 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-08-18 | 536 | $452.96 | $242,787 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-08-18 | 886 | $454.04 | $402,279 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-08-18 | 392 | $454.84 | $178,297 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-08-18 | 19 | $455.82 | $8,661 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-08-18 | 12 | $455.82 | $5,470 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-08-18 | 241 | $454.84 | $109,616 | Disposed | EDGAR |
| ALNY | BONNEY MICHAEL W | Director | Sale | 2025-08-18 | 11,250 | $450.00 | $5,062,500 | Disposed | EDGAR |
| ALNY | BONNEY MICHAEL W | Director | Option exercise | 2025-08-18 | 11,250 | $70.20 | $789,750 | Acquired | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-08-18 | 194 | $447.98 | $86,908 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-08-18 | 450 | $449.92 | $202,464 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-08-18 | 195 | $450.92 | $87,929 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-08-18 | 514 | $451.99 | $232,323 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-08-18 | 1,646 | $452.96 | $745,572 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-08-18 | 2,716 | $454.04 | $1,233,173 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-08-18 | 1,204 | $454.84 | $547,627 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-08-18 | 60 | $455.82 | $27,349 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Award | 2025-08-15 | 2,851 | — | — | Acquired | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Award | 2025-08-15 | 14,252 | — | — | Acquired | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Award | 2025-08-15 | 2,851 | — | — | Acquired | EDGAR |
| ALNY | Garg Pushkal | EVP Chief R&D | Award | 2025-08-15 | 2,851 | — | — | Acquired | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Award | 2025-08-15 | 4,644 | — | — | Acquired | EDGAR |
| ALNY | Ausiello Dennis A | Director | Option exercise | 2025-08-14 | 9,000 | $72.01 | $648,090 | Acquired | EDGAR |
| ALNY | Ausiello Dennis A | Director | Sale | 2025-08-14 | 2,098 | $434.50 | $911,581 | Disposed | EDGAR |
| ALNY | Ausiello Dennis A | Director | Sale | 2025-08-14 | 1,938 | $432.94 | $839,038 | Disposed | EDGAR |
| ALNY | Ausiello Dennis A | Director | Sale | 2025-08-14 | 1,985 | $430.81 | $855,158 | Disposed | EDGAR |
| ALNY | Ausiello Dennis A | Director | Option exercise | 2025-08-14 | 3,454 | $189.87 | $655,811 | Acquired | EDGAR |
| ALNY | Ausiello Dennis A | Director | Option exercise | 2025-08-14 | 4,032 | $171.95 | $693,302 | Acquired | EDGAR |
| ALNY | Ausiello Dennis A | Director | Option exercise | 2025-08-14 | 5,228 | $151.22 | $790,578 | Acquired | EDGAR |
| ALNY | Ausiello Dennis A | Director | Option exercise | 2025-08-14 | 4,581 | $148.77 | $681,515 | Acquired | EDGAR |
| ALNY | Ausiello Dennis A | Director | Option exercise | 2025-08-14 | 5,153 | $128.31 | $661,181 | Acquired | EDGAR |
| ALNY | Ausiello Dennis A | Director | Sale | 2025-08-14 | 5,302 | $439.27 | $2,329,010 | Disposed | EDGAR |
| ALNY | Ausiello Dennis A | Director | Sale | 2025-08-14 | 1,238 | $440.54 | $545,389 | Disposed | EDGAR |
| ALNY | Ausiello Dennis A | Director | Sale | 2025-08-14 | 1,205 | $441.88 | $532,465 | Disposed | EDGAR |
| ALNY | Ausiello Dennis A | Director | Sale | 2025-08-14 | 641 | $442.66 | $283,745 | Disposed | EDGAR |
| ALNY | Ausiello Dennis A | Director | Sale | 2025-08-14 | 2,086 | $438.34 | $914,377 | Disposed | EDGAR |
| ALNY | Ausiello Dennis A | Director | Sale | 2025-08-14 | 1,922 | $437.56 | $840,990 | Disposed | EDGAR |
| ALNY | Ausiello Dennis A | Director | Sale | 2025-08-14 | 5,358 | $436.00 | $2,336,088 | Disposed | EDGAR |
| ALNY | Ausiello Dennis A | Director | Sale | 2025-08-14 | 7,675 | $435.40 | $3,341,695 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Award | 2025-07-01 | 7,763 | — | — | Acquired | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-06-02 | 19,297 | $306.00 | $5,904,882 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Option exercise | 2025-06-02 | 12,080 | $119.13 | $1,439,090 | Acquired | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Option exercise | 2025-06-02 | 7,217 | $118.05 | $851,967 | Acquired | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-05-30 | 6,171 | $306.00 | $1,888,326 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-05-30 | 25,469 | $304.00 | $7,742,576 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Option exercise | 2025-05-30 | 12,081 | $119.13 | $1,439,210 | Acquired | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Option exercise | 2025-05-30 | 19,559 | $118.05 | $2,308,940 | Acquired | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Gift | 2025-05-16 | 8,376 | — | — | Disposed | EDGAR |
| ALNY | BONNEY MICHAEL W | Director | Sale | 2025-05-15 | 1,617 | $283.83 | $458,953 | Disposed | EDGAR |
| ALNY | BONNEY MICHAEL W | Director | Sale | 2025-05-15 | 729 | $268.56 | $195,780 | Disposed | EDGAR |
| ALNY | BONNEY MICHAEL W | Director | Sale | 2025-05-15 | 549 | $267.14 | $146,660 | Disposed | EDGAR |
| ALNY | BONNEY MICHAEL W | Director | Option exercise | 2025-05-15 | 11,250 | $131.21 | $1,476,112 | Acquired | EDGAR |
| ALNY | BONNEY MICHAEL W | Director | Sale | 2025-05-15 | 245 | $269.79 | $66,099 | Disposed | EDGAR |
| ALNY | BONNEY MICHAEL W | Director | Sale | 2025-05-15 | 431 | $271.68 | $117,094 | Disposed | EDGAR |
| ALNY | BONNEY MICHAEL W | Director | Sale | 2025-05-15 | 660 | $273.16 | $180,286 | Disposed | EDGAR |
| ALNY | BONNEY MICHAEL W | Director | Sale | 2025-05-15 | 882 | $273.75 | $241,448 | Disposed | EDGAR |
| ALNY | BONNEY MICHAEL W | Director | Sale | 2025-05-15 | 301 | $275.63 | $82,965 | Disposed | EDGAR |
| ALNY | BONNEY MICHAEL W | Director | Sale | 2025-05-15 | 1,263 | $277.16 | $350,053 | Disposed | EDGAR |
| ALNY | BONNEY MICHAEL W | Director | Sale | 2025-05-15 | 1,239 | $278.01 | $344,454 | Disposed | EDGAR |
| ALNY | BONNEY MICHAEL W | Director | Sale | 2025-05-15 | 432 | $280.03 | $120,973 | Disposed | EDGAR |
| ALNY | BONNEY MICHAEL W | Director | Sale | 2025-05-15 | 372 | $281.10 | $104,569 | Disposed | EDGAR |
| ALNY | BONNEY MICHAEL W | Director | Sale | 2025-05-15 | 802 | $282.03 | $226,188 | Disposed | EDGAR |
| ALNY | BONNEY MICHAEL W | Director | Sale | 2025-05-15 | 1,728 | $282.81 | $488,696 | Disposed | EDGAR |
| ALNY | Sigal Charles Elliott | Director | Award | 2025-05-08 | 775 | — | — | Acquired | EDGAR |
| ALNY | BONNEY MICHAEL W | Director | Award | 2025-05-08 | 775 | — | — | Acquired | EDGAR |
| ALNY | SCHULMAN AMY W | Director | Award | 2025-05-08 | 775 | — | — | Acquired | EDGAR |
| ALNY | PYOTT DAVID E I | Director | Award | 2025-05-08 | 775 | — | — | Acquired | EDGAR |
| ALNY | BRANDICOURT OLIVIER | Director | Award | 2025-05-08 | 775 | — | — | Acquired | EDGAR |
| ALNY | HAMBURG MARGARET A | Director | Award | 2025-05-08 | 775 | — | — | Acquired | EDGAR |
| ALNY | Reitan Colleen F | Director | Award | 2025-05-08 | 775 | — | — | Acquired | EDGAR |
| ALNY | Ausiello Dennis A | Director | Award | 2025-05-08 | 775 | — | — | Acquired | EDGAR |
| ALNY | KELLOGG PETER N | Director | Award | 2025-05-08 | 775 | — | — | Acquired | EDGAR |
| ALNY | Bertozzi Carolyn R | Director | Award | 2025-05-08 | 775 | — | — | Acquired | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Gift | 2025-05-02 | 41,311 | — | — | Disposed | EDGAR |
| ALNY | Reitan Colleen F | Director | Sale | 2025-04-16 | 36 | $232.86 | $8,383 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Option exercise | 2025-03-24 | 5,445 | $42.22 | $229,888 | Acquired | EDGAR |
| ALNY | PYOTT DAVID E I | Director | Option exercise | 2025-03-24 | 7,440 | $88.95 | $661,788 | Acquired | EDGAR |
| ALNY | PYOTT DAVID E I | Director | Sale | 2025-03-24 | 7,440 | $299.00 | $2,224,560 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-03-24 | 5,445 | $300.00 | $1,633,500 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-03-21 | 4,321 | $285.00 | $1,231,485 | Disposed | EDGAR |
| ALNY | SCHULMAN AMY W | Director | Option exercise | 2025-03-13 | 2,750 | $131.21 | $360,828 | Acquired | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-03-04 | 324 | $241.68 | $78,304 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-03-04 | 147 | $239.25 | $35,170 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-03-04 | 343 | $240.92 | $82,636 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-03-04 | 198 | $241.60 | $47,837 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-03-04 | 120 | $242.70 | $29,124 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-03-04 | 121 | $239.24 | $28,948 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-03-04 | 328 | $240.95 | $79,032 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-03-04 | 71 | $242.93 | $17,248 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-03-03 | 48 | $246.18 | $11,817 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-03-03 | 116 | $245.26 | $28,450 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-03-03 | 158 | $244.41 | $38,617 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-03-03 | 235 | $243.36 | $57,190 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-03-03 | 1 | $248.36 | $248 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-03-03 | 7 | $247.35 | $1,731 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-03-03 | 77 | $246.18 | $18,956 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-03-03 | 189 | $245.26 | $46,354 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-03-03 | 258 | $244.41 | $63,058 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-03-03 | 382 | $243.36 | $92,964 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-03-03 | 3 | $247.35 | $742 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-03-03 | 29 | $246.18 | $7,139 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-03-03 | 70 | $245.26 | $17,168 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-03-03 | 96 | $244.41 | $23,463 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-03-03 | 142 | $243.36 | $34,557 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-03-03 | 131 | $242.37 | $31,750 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Award | 2025-03-03 | 14,137 | — | — | Acquired | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-03-03 | 213 | $242.37 | $51,625 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-03-03 | 4 | $248.36 | $993 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-03-03 | 23 | $247.35 | $5,689 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-03-03 | 238 | $246.18 | $58,591 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-03-03 | 580 | $245.26 | $142,251 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-03-03 | 350 | $242.37 | $84,830 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Award | 2025-03-03 | 15,117 | — | — | Acquired | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-03-03 | 791 | $244.41 | $193,328 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-03-03 | 1,173 | $243.36 | $285,461 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-03-03 | 1,068 | $242.37 | $258,851 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Award | 2025-03-03 | 17,965 | — | — | Acquired | EDGAR |
| ALNY | Hesslein Robert W. | EVP, CLO and Secretary | Award | 2025-03-03 | 757 | — | — | Acquired | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Award | 2025-03-03 | 14,137 | — | — | Acquired | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-03-03 | 117 | $245.53 | $28,727 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-03-03 | 273 | $244.43 | $66,729 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Award | 2025-03-03 | 3,871 | — | — | Acquired | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-03-03 | 204 | $242.37 | $49,443 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-03-03 | 224 | $243.36 | $54,513 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-03-03 | 151 | $244.41 | $36,906 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-03-03 | 111 | $245.26 | $27,224 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-03-03 | 45 | $246.18 | $11,078 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-03-03 | 4 | $247.35 | $989 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-03-03 | 1 | $248.36 | $248 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-03-03 | 465 | $242.69 | $112,851 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-03-03 | 487 | $243.94 | $118,799 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-03-03 | 219 | $245.30 | $53,721 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-03-03 | 5 | $247.35 | $1,237 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-03-03 | 1 | $248.36 | $248 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-03-03 | 583 | $243.13 | $141,745 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-02-28 | 158 | $236.51 | $37,369 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-02-28 | 35 | $239.18 | $8,371 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-02-28 | 34 | $238.33 | $8,103 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-02-28 | 42 | $236.51 | $9,933 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-02-28 | 27 | $236.51 | $6,386 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-02-28 | 21 | $238.33 | $5,005 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-02-28 | 22 | $239.18 | $5,262 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-02-28 | 48 | $240.32 | $11,535 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-02-28 | 79 | $241.51 | $19,079 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-02-28 | 187 | $242.44 | $45,336 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-02-28 | 75 | $243.23 | $18,242 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-02-28 | 37 | $244.11 | $9,032 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-02-28 | 123 | $238.33 | $29,315 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-02-28 | 127 | $239.18 | $30,376 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-02-28 | 51 | $236.51 | $12,062 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-02-28 | 40 | $238.33 | $9,533 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-02-28 | 41 | $239.18 | $9,806 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-02-28 | 91 | $240.32 | $21,869 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-02-28 | 149 | $241.51 | $35,985 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-02-28 | 352 | $242.44 | $85,339 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-02-28 | 142 | $243.23 | $34,539 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-02-28 | 69 | $244.11 | $16,844 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-02-28 | 284 | $240.32 | $68,251 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-02-28 | 461 | $241.51 | $111,336 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-02-28 | 1,093 | $242.44 | $264,987 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-02-28 | 440 | $243.23 | $107,021 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-02-28 | 214 | $244.11 | $52,240 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-02-28 | 78 | $240.32 | $18,745 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-02-28 | 127 | $241.51 | $30,672 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-02-28 | 300 | $242.44 | $72,732 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-02-28 | 121 | $243.23 | $29,431 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-02-28 | 59 | $244.11 | $14,402 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-02-28 | 28 | $236.51 | $6,622 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-02-28 | 22 | $238.33 | $5,243 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-02-28 | 23 | $239.18 | $5,501 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-02-28 | 50 | $240.32 | $12,016 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-02-28 | 82 | $241.51 | $19,804 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-02-28 | 192 | $242.44 | $46,548 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-02-28 | 78 | $243.23 | $18,972 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2025-02-28 | 38 | $244.11 | $9,276 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Option exercise | 2025-02-27 | 5,921 | — | — | Acquired | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Option exercise | 2025-02-27 | 1,908 | — | — | Acquired | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Option exercise | 2025-02-27 | 1,667 | — | — | Acquired | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Option exercise | 2025-02-27 | 1,908 | — | — | Acquired | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-02-18 | 80 | $259.10 | $20,728 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-02-18 | 107 | $257.99 | $27,605 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-02-18 | 83 | $259.10 | $21,505 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-02-18 | 306 | $250.73 | $76,723 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-02-18 | 115 | $251.60 | $28,934 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-02-18 | 110 | $251.60 | $27,676 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-02-18 | 862 | $250.11 | $215,595 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-02-18 | 80 | $256.05 | $20,484 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-02-18 | 1,086 | $250.21 | $271,728 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-02-18 | 76 | $257.79 | $19,592 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-02-18 | 83 | $256.05 | $21,252 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-02-14 | 60 | $257.51 | $15,451 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-02-14 | 77 | $258.07 | $19,871 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-02-14 | 27 | $259.72 | $7,012 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-02-14 | 49 | $260.57 | $12,768 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-02-14 | 164 | $253.37 | $41,553 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-02-14 | 47 | $255.56 | $12,011 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-02-14 | 12 | $259.72 | $3,117 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-02-14 | 98 | $256.29 | $25,116 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-02-14 | 47 | $257.51 | $12,103 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-02-14 | 59 | $258.07 | $15,226 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-02-14 | 21 | $259.72 | $5,454 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-02-14 | 38 | $260.57 | $9,902 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-02-14 | 33 | $258.07 | $8,516 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-02-14 | 26 | $257.51 | $6,695 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-02-14 | 53 | $256.29 | $13,583 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-02-14 | 25 | $264.87 | $6,622 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-02-14 | 258 | $254.35 | $65,622 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-02-14 | 110 | $255.56 | $28,112 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-02-14 | 126 | $256.29 | $32,293 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-02-14 | 239 | $253.37 | $60,555 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-02-14 | 160 | $254.35 | $40,696 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-02-14 | 68 | $255.56 | $17,378 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-02-14 | 78 | $256.29 | $19,991 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-02-14 | 37 | $257.51 | $9,528 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-02-14 | 47 | $258.07 | $12,129 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-02-14 | 17 | $259.72 | $4,415 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-02-14 | 30 | $260.57 | $7,817 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-02-14 | 20 | $264.87 | $5,297 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-02-14 | 386 | $253.37 | $97,801 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-02-14 | 21 | $260.57 | $5,472 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-02-14 | 14 | $264.87 | $3,708 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-02-14 | 32 | $264.87 | $8,476 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-02-14 | 349 | $252.50 | $88,122 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-02-14 | 271 | $252.50 | $68,428 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-02-14 | 300 | $253.37 | $76,011 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-02-14 | 201 | $254.35 | $51,124 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2025-02-14 | 85 | $255.56 | $21,723 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-02-14 | 145 | $252.50 | $36,612 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2025-02-14 | 110 | $254.35 | $27,978 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2025-02-14 | 217 | $252.50 | $54,792 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Award | 2025-02-13 | 3,109 | — | — | Acquired | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Award | 2025-02-13 | 2,103 | — | — | Acquired | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Award | 2025-02-13 | 3,109 | — | — | Acquired | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Award | 2025-02-13 | 3,859 | — | — | Acquired | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2025-01-27 | 52,592 | $285.00 | $14,988,720 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Option exercise | 2025-01-27 | 25,000 | $88.95 | $2,223,750 | Acquired | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Option exercise | 2025-01-27 | 23,876 | $88.95 | $2,123,770 | Acquired | EDGAR |
| ALNY | SHARP PHILLIP A | Director | Sale | 2025-01-23 | 11,250 | $275.00 | $3,093,750 | Disposed | EDGAR |
| ALNY | SHARP PHILLIP A | Director | Option exercise | 2025-01-23 | 11,250 | $131.21 | $1,476,112 | Acquired | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2024-12-12 | 100 | $252.94 | $25,294 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2024-12-12 | 140 | $254.37 | $35,612 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2024-12-12 | 1 | $255.80 | $256 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2024-12-12 | 121 | $247.48 | $29,945 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2024-12-12 | 186 | $248.99 | $46,312 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2024-12-12 | 426 | $250.08 | $106,534 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2024-12-12 | 778 | $251.68 | $195,807 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2024-11-27 | 210 | $250.45 | $52,594 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2024-11-27 | 110 | $254.48 | $27,993 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2024-11-27 | 851 | $251.98 | $214,435 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2024-11-27 | 360 | $253.44 | $91,238 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2024-11-26 | 30 | $247.77 | $7,433 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2024-11-26 | 26 | $247.77 | $6,442 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2024-11-26 | 215 | $249.60 | $53,664 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2024-11-26 | 318 | $250.68 | $79,716 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2024-11-26 | 826 | $251.42 | $207,673 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Sale | 2024-11-26 | 84 | $252.27 | $21,191 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2024-11-26 | 26 | $247.77 | $6,442 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2024-11-26 | 215 | $249.60 | $53,664 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2024-11-26 | 318 | $250.68 | $79,716 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2024-11-26 | 826 | $251.42 | $207,673 | Disposed | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Sale | 2024-11-26 | 84 | $252.27 | $21,191 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2024-11-26 | 300 | $252.27 | $75,681 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2024-11-26 | 2,933 | $251.42 | $737,415 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2024-11-26 | 1,131 | $250.68 | $283,519 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2024-11-26 | 762 | $249.60 | $190,195 | Disposed | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Sale | 2024-11-26 | 93 | $247.77 | $23,043 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2024-11-26 | 246 | $249.60 | $61,402 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2024-11-26 | 30 | $247.77 | $7,433 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2024-11-26 | 364 | $250.68 | $91,248 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2024-11-26 | 945 | $251.42 | $237,592 | Disposed | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Sale | 2024-11-26 | 97 | $252.27 | $24,470 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2024-11-26 | 97 | $252.27 | $24,470 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2024-11-26 | 945 | $251.42 | $237,592 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2024-11-26 | 364 | $250.68 | $91,248 | Disposed | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale | 2024-11-26 | 246 | $249.60 | $61,402 | Disposed | EDGAR |
| ALNY | Tanguler Tolga | EVP, Chief Commercial Officer | Award | 2024-11-25 | 3,000 | — | — | Acquired | EDGAR |
| ALNY | Poulton Jeffrey V. | EVP, Chief Financial Officer | Award | 2024-11-25 | 3,434 | — | — | Acquired | EDGAR |
| ALNY | Greenstreet Yvonne | Chief Executive Officer | Award | 2024-11-25 | 10,658 | — | — | Acquired | EDGAR |
| ALNY | Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | Award | 2024-11-25 | 3,000 | — | — | Acquired | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Award | 2024-11-25 | 3,434 | — | — | Acquired | EDGAR |
| ALNY | Reitan Colleen F | Director | Purchase | 2024-10-17 | 4 | $302.67 | $1,211 | Acquired | EDGAR |
| ALNY | Garg Pushkal | CMO & EVP Dev & Med Affairs | Award | 2024-10-08 | 96 | — | — | Acquired | EDGAR |
| ALNY | Hesslein Robert W. | EVP, CLO and Secretary | Award | 2024-10-01 | 7,245 | — | — | Acquired | EDGAR |
| ALNY | Reitan Colleen F | Director | Purchase | 2024-08-29 | 32 | $286.00 | $9,152 | Acquired | EDGAR |
Long US-equity 13F disclosures only · up to 45-day reporting lag · sells = reduce/avoid, not short.
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