Arbo · 13F Signal Engine

Insider

Form 4/4-A open-market insider transactions (officers, directors, 10% owners) · 369 transactions

Table I (non-derivative) transactions only -- common stock bought, sold, awarded, exercised, or tax-withheld. Covers this app's full ticker Universe (backfilled INSIDER_LOOKBACK_QUARTERS quarters back, continuously monitored) plus whatever the market-wide discovery has found beyond it. Informational only: never summed into the core flow ranking.

Ticker	Insider	Role	Type	Date	Shares	Price	Value	Notes	Filing
ONC	BAKER BROS. ADVISORS LP	Director	Option exercise	2026-09-14	30,768	$36.83	$1,133,185	Acquired (761,410 owned after)	EDGAR
ONC	Wang Xiaodong	Director	Sale 10b5-1	2026-09-08	10,688	$349.28	$3,733,141	Disposed (12,847 owned after)	EDGAR
ONC	Wang Xiaodong	Director	Sale 10b5-1	2026-09-08	7,492	$348.31	$2,609,573	Disposed (23,535 owned after)	EDGAR
ONC	Wang Xiaodong	Director	Option exercise 10b5-1	2026-09-08	31,027	$36.90	$1,144,896	Acquired (31,027 owned after)	EDGAR
ONC	Wang Xiaodong	Director	Sale 10b5-1	2026-09-08	1,181	$345.38	$407,897	Disposed (6,079 owned after)	EDGAR
ONC	Wang Xiaodong	Director	Sale 10b5-1	2026-09-08	2,841	$346.16	$983,433	Disposed (3,238 owned after)	EDGAR
ONC	Wang Xiaodong	Director	Sale 10b5-1	2026-09-08	1,517	$347.39	$526,993	Disposed (1,721 owned after)	EDGAR
ONC	Wang Xiaodong	Director	Sale 10b5-1	2026-09-08	1,721	$348.01	$598,930	Disposed (0 owned after)	EDGAR
ONC	Wang Xiaodong	Director	Sale 10b5-1	2026-09-08	6,569	$350.27	$2,300,951	Disposed (6,278 owned after)	EDGAR
ONC	Wang Xiaodong	Director	Sale 10b5-1	2026-09-08	6,278	$351.25	$2,205,174	Disposed (0 owned after)	EDGAR
ONC	Ball Titus B.	Principal Accounting Officer	Sale	2026-09-01	132	$355.86	$46,974	Disposed (0 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale 10b5-1	2026-08-25	280	$380.00	$106,400	Disposed (0 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-08-12	2,515	$356.43	$896,426	Disposed (50,397 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-08-12	14,102	$359.12	$5,064,252	Disposed (0 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-08-12	15,396	$357.63	$5,506,147	Disposed (35,001 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-08-12	1,980	$354.71	$702,320	Disposed (52,912 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-08-12	20,899	$358.41	$7,490,448	Disposed (14,102 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-08-11	5,211	$364.31	$1,898,442	Disposed (59,272 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Sale 10b5-1	2026-08-11	2,666	$360.00	$959,760	Disposed (0 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2026-08-11	796	$159.03	$126,588	Acquired (2,666 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2026-08-11	1,058	$213.32	$225,693	Acquired (1,870 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-08-11	13,695	$359.32	$4,920,844	Disposed (112,104 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-08-11	8,081	$360.33	$2,911,849	Disposed (104,023 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-08-11	14,569	$361.47	$5,266,268	Disposed (89,454 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-08-11	11,568	$362.34	$4,191,548	Disposed (77,886 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-08-11	13,403	$363.45	$4,871,344	Disposed (64,483 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-08-11	3,176	$365.26	$1,160,079	Disposed (56,096 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-08-11	1,200	$366.31	$439,574	Disposed (54,896 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-08-11	4	$367.00	$1,468	Disposed (54,892 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2026-08-11	812	$194.47	$157,910	Acquired (812 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-08-10	45,044	$358.70	$16,157,076	Disposed (150,733 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-08-10	21,254	$359.50	$7,640,826	Disposed (129,479 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-08-10	3,680	$360.63	$1,327,130	Disposed (125,799 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-08-10	67	$350.00	$23,450	Disposed (240,743 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-08-10	2,813	$351.80	$989,603	Disposed (237,930 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-08-10	3,673	$353.32	$1,297,741	Disposed (234,257 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-08-10	6,717	$354.78	$2,383,028	Disposed (227,540 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-08-10	3,476	$355.66	$1,236,261	Disposed (224,064 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-08-10	12,418	$356.62	$4,428,482	Disposed (211,646 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-08-10	15,869	$357.67	$5,675,864	Disposed (195,777 owned after)	EDGAR
ONC	Rosenberg Aaron	Chief Financial Officer	Sale	2026-08-03	1,157	$312.71	$361,811	Disposed (0 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Sale	2026-07-30	1,044	$323.69	$337,932	Disposed (0 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Sale 10b5-1	2026-07-22	1,669	$325.00	$542,425	Disposed (0 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2026-07-22	514	$194.47	$99,958	Acquired (514 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2026-07-22	665	$213.32	$141,858	Acquired (1,179 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2026-07-22	490	$159.03	$77,925	Acquired (1,669 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-21	15,807	$319.29	$5,047,019	Disposed (2,340 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-21	15,379	$316.26	$4,863,766	Disposed (46,018 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-21	2,340	$320.06	$748,936	Disposed (0 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-21	20,029	$316.91	$6,347,340	Disposed (25,989 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-21	7,842	$318.41	$2,496,997	Disposed (18,147 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-20	5,146	$310.08	$1,595,678	Disposed (9,180 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-20	2,907	$311.80	$906,389	Disposed (0 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Option exercise 10b5-1	2026-07-20	33,990	$119.96	$4,077,440	Acquired (33,990 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-20	15,499	$312.29	$4,840,115	Disposed (18,491 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-20	14,326	$312.96	$4,483,433	Disposed (4,165 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-20	280	$318.30	$89,124	Disposed (0 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-20	523	$316.14	$165,339	Disposed (280 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-20	1,512	$315.26	$476,678	Disposed (803 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-20	1,850	$313.91	$580,732	Disposed (2,315 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-20	6,273	$310.75	$1,949,310	Disposed (2,907 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-17	1,440	$305.20	$439,486	Disposed (63,188 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-17	597	$306.96	$183,258	Disposed (62,591 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-17	680	$309.05	$210,157	Disposed (61,911 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-17	4,833	$310.37	$1,500,015	Disposed (57,078 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-17	5,543	$311.42	$1,726,218	Disposed (51,535 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-17	35,829	$312.17	$11,184,911	Disposed (15,706 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-17	14,915	$313.19	$4,671,198	Disposed (791 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-17	740	$314.32	$232,597	Disposed (51 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-17	51	$315.06	$16,068	Disposed (0 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Option exercise 10b5-1	2026-07-17	64,628	$119.96	$7,752,775	Acquired (64,628 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-16	20,505	$321.00	$6,582,064	Disposed (15,189 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Option exercise 10b5-1	2026-07-16	96,501	$160.40	$15,478,760	Acquired (96,501 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Option exercise 10b5-1	2026-07-16	70,096	$119.96	$8,408,716	Acquired (166,597 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-16	233	$311.98	$72,691	Disposed (166,364 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-16	4,881	$314.08	$1,533,011	Disposed (161,483 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-16	520	$323.59	$168,265	Disposed (0 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-16	1,560	$322.71	$503,424	Disposed (520 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-16	13,109	$321.61	$4,216,021	Disposed (2,080 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-16	15,097	$319.99	$4,830,934	Disposed (35,694 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-16	6,402	$318.55	$2,039,353	Disposed (50,791 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-16	42,798	$317.79	$13,600,721	Disposed (57,193 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-16	32,224	$316.82	$10,209,121	Disposed (99,991 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-16	19,752	$316.00	$6,241,632	Disposed (132,215 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-16	9,516	$314.73	$2,994,988	Disposed (151,967 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Option exercise 10b5-1	2026-07-15	76,677	$169.58	$13,002,886	Acquired (112,282 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Option exercise 10b5-1	2026-07-15	4,275	$160.40	$685,710	Acquired (116,557 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-15	6,067	$310.02	$1,880,892	Disposed (110,490 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-15	41,336	$310.92	$12,852,305	Disposed (69,154 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-15	48,657	$312.86	$15,222,746	Disposed (7,640 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-15	12,857	$311.71	$4,007,685	Disposed (56,297 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Option exercise 10b5-1	2026-07-15	35,605	$100.04	$3,561,924	Acquired (35,605 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-15	7,640	$313.58	$2,395,746	Disposed (0 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-14	40,781	$306.93	$12,517,112	Disposed (7,834 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-14	45,895	$306.21	$14,053,627	Disposed (48,615 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-14	39,090	$305.02	$11,923,259	Disposed (94,510 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Option exercise 10b5-1	2026-07-14	36,318	$100.04	$3,633,253	Acquired (133,600 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Option exercise 10b5-1	2026-07-14	97,282	$36.90	$3,589,706	Acquired (97,282 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-14	8,122	$303.93	$2,468,490	Disposed (0 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-14	4,139	$303.07	$1,254,401	Disposed (8,122 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-14	7,834	$307.57	$2,409,534	Disposed (0 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-13	320	$307.40	$98,370	Disposed (0 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Option exercise 10b5-1	2026-07-13	48,520	$36.90	$1,790,388	Acquired (48,520 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-13	798	$301.94	$240,945	Disposed (47,722 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-13	4,584	$302.79	$1,387,981	Disposed (43,138 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-13	26,294	$303.83	$7,988,777	Disposed (16,844 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-13	8,438	$304.68	$2,570,892	Disposed (8,406 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-13	846	$305.57	$258,508	Disposed (7,560 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-13	7,240	$306.82	$2,221,409	Disposed (320 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-10	3,074	$298.35	$917,133	Disposed (5,817 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-10	1,314	$297.23	$390,561	Disposed (8,891 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-10	1,493	$296.07	$442,028	Disposed (10,205 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Option exercise 10b5-1	2026-07-10	11,698	$36.90	$431,656	Acquired (11,698 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-10	18	$303.03	$5,455	Disposed (0 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-10	136	$302.19	$41,098	Disposed (18 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-10	150	$301.18	$45,177	Disposed (154 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-10	370	$300.12	$111,044	Disposed (304 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2026-07-10	5,143	$298.94	$1,537,429	Disposed (674 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2026-07-08	202	$194.47	$39,283	Acquired (202 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2026-07-08	196	$159.03	$31,170	Acquired (664 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2026-07-08	266	$213.32	$56,743	Acquired (468 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Sale 10b5-1	2026-07-08	664	$302.46	$200,833	Disposed (0 owned after)	EDGAR
ONC	Wang Lai	President, Global Head of R&D	Sale	2026-06-23	1,068	$276.74	$295,553	Disposed (0 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale	2026-06-23	1,290	$274.12	$353,613	Disposed (320 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale	2026-06-23	1,292	$276.26	$356,927	Disposed (0 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale	2026-06-23	320	$275.10	$88,030	Disposed (0 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale	2026-06-23	1,800	$273.30	$491,949	Disposed (1,610 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Sale	2026-06-16	590	$265.98	$156,925	Disposed (0 owned after)	EDGAR
ONC	Wang Lai	President, Global Head of R&D	Sale	2026-06-16	1,169	$265.39	$310,236	Disposed (0 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale	2026-06-16	333	$266.69	$88,809	Disposed (0 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale	2026-06-16	1,710	$265.99	$454,835	Disposed (333 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale	2026-06-16	1,650	$264.87	$437,042	Disposed (2,043 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale	2026-06-16	1,357	$266.76	$361,997	Disposed (0 owned after)	EDGAR
ONC	BRANDICOURT OLIVIER	Director	Award	2026-06-11	18,980	—	—	Acquired (46,306 owned after)	EDGAR
ONC	Rosenberg Aaron	Chief Financial Officer	Sale	2026-06-11	631	$257.74	$162,637	Disposed (0 owned after)	EDGAR
ONC	Rosenberg Aaron	Chief Financial Officer	Award	2026-06-11	71,175	—	—	Acquired (397,891 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Award	2026-06-11	45,071	—	—	Acquired (346,554 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Sale	2026-06-11	428	$257.63	$110,268	Disposed (0 owned after)	EDGAR
ONC	Mooney Elizabeth Fisher	Director	Award	2026-06-11	18,980	—	—	Acquired (18,980 owned after)	EDGAR
ONC	Ball Titus B.	Principal Accounting Officer	Sale	2026-06-11	120	$257.53	$30,904	Disposed (0 owned after)	EDGAR
ONC	Ball Titus B.	Principal Accounting Officer	Sale	2026-06-11	49	$256.39	$12,563	Disposed (120 owned after)	EDGAR
ONC	Ball Titus B.	Principal Accounting Officer	Award	2026-06-11	31,213	—	—	Acquired (99,645 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Award	2026-06-11	118,625	—	—	Acquired (1,308,161 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale	2026-06-11	626	$261.20	$163,512	Disposed (0 owned after)	EDGAR
ONC	HOOPER ANTHONY C	Director	Award	2026-06-11	18,980	—	—	Acquired (83,720 owned after)	EDGAR
ONC	Wang Lai	President, Global Head of R&D	Award	2026-06-11	118,625	—	—	Acquired (1,710,085 owned after)	EDGAR
ONC	Wang Lai	President, Global Head of R&D	Sale	2026-06-11	756	$261.00	$197,318	Disposed (0 owned after)	EDGAR
ONC	Wang Xiaodong	Director	Award	2026-06-11	99,892	—	—	Acquired (4,682,493 owned after)	EDGAR
ONC	Sawyers Charles Lazelle	Director	Award	2026-06-11	18,980	—	—	Acquired (18,984 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Award	2026-06-11	177,931	—	—	Acquired (5,697,649 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale	2026-06-11	741	$256.23	$189,865	Disposed (1,208 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale	2026-06-11	859	$257.59	$221,271	Disposed (349 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale	2026-06-11	200	$258.28	$51,656	Disposed (149 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale	2026-06-11	149	$258.81	$38,563	Disposed (0 owned after)	EDGAR
ONC	Dugan Margaret	Director	Award	2026-06-11	18,980	—	—	Acquired (73,164 owned after)	EDGAR
ONC	BAKER BROS. ADVISORS LP	Director	Award	2026-06-11	18,980	—	—	Acquired (161,546 owned after)	EDGAR
ONC	Sharp Shalini	Director	Award	2026-06-11	18,980	—	—	Acquired (38,116 owned after)	EDGAR
ONC	Riva Alessandro	Director	Award	2026-06-11	18,980	—	—	Acquired (73,164 owned after)	EDGAR
ONC	Ball Titus B.	Principal Accounting Officer	Sale	2026-06-08	100	$271.06	$27,106	Disposed (36 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale	2026-06-08	40	$270.55	$10,822	Disposed (0 owned after)	EDGAR
ONC	Wang Lai	President, Global Head of R&D	Sale	2026-06-08	1,327	$269.34	$357,418	Disposed (40 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale	2026-06-08	3,820	$270.38	$1,032,870	Disposed (1,120 owned after)	EDGAR
ONC	Wang Lai	President, Global Head of R&D	Sale	2026-06-08	40	$270.73	$10,829	Disposed (0 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Sale	2026-06-08	160	$271.26	$43,401	Disposed (0 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale	2026-06-08	1,120	$271.14	$303,678	Disposed (0 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Sale	2026-06-08	711	$270.24	$192,138	Disposed (160 owned after)	EDGAR
ONC	Ball Titus B.	Principal Accounting Officer	Sale	2026-06-08	36	$272.08	$9,795	Disposed (0 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale	2026-06-08	1,444	$269.33	$388,916	Disposed (40 owned after)	EDGAR
ONC	Yi Qingqing	Director	Sale	2026-06-01	235	$279.13	$65,596	Disposed (0 owned after)	EDGAR
ONC	BAKER BROS. ADVISORS LP	Director	Sale	2026-05-22	2,756	$23.79	$65,567	Disposed (142,566 owned after)	EDGAR
ONC	Sanders Corazon (Corsee) D.	Director	Sale	2026-05-22	212	$309.59	$65,633	Disposed (0 owned after)	EDGAR
ONC	Dugan Margaret	Director	Sale	2026-05-22	212	$309.60	$65,636	Disposed (0 owned after)	EDGAR
ONC	BAKER BROS. ADVISORS LP	Director	Sale	2026-05-22	2,743	$23.85	$65,424	Disposed (145,322 owned after)	EDGAR
ONC	Riva Alessandro	Director	Sale	2026-05-22	212	$309.51	$65,617	Disposed (0 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2026-05-13	98	$159.03	$15,585	Acquired (332 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2026-05-13	133	$213.32	$28,372	Acquired (234 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2026-05-13	101	$194.47	$19,641	Acquired (101 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Sale 10b5-1	2026-05-13	332	$310.72	$103,159	Disposed (0 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2026-04-08	101	$194.47	$19,641	Acquired (101 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Sale 10b5-1	2026-04-08	332	$311.59	$103,448	Disposed (0 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2026-04-08	98	$159.03	$15,585	Acquired (332 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2026-04-08	133	$213.32	$28,372	Acquired (234 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Sale 10b5-1	2026-03-11	341	$300.00	$102,300	Disposed (0 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2026-03-11	133	$213.32	$28,372	Acquired (243 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2026-03-11	110	$194.47	$21,392	Acquired (110 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2026-03-11	98	$159.03	$15,585	Acquired (341 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Award	2026-03-06	117,936	—	—	Acquired (5,609,275 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Award	2026-03-06	65,390	—	—	Acquired (288,496 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Award	2026-03-06	29,874	—	—	Acquired (318,370 owned after)	EDGAR
ONC	Rosenberg Aaron	Chief Financial Officer	Award	2026-03-06	79,014	—	—	Acquired (294,346 owned after)	EDGAR
ONC	Rosenberg Aaron	Chief Financial Officer	Award	2026-03-06	40,573	—	—	Acquired (334,919 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Award	2026-03-06	78,624	—	—	Acquired (1,216,524 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Award	2026-03-06	168,922	—	—	Acquired (1,137,900 owned after)	EDGAR
ONC	Wang Lai	President, Global Head of R&D	Award	2026-03-06	55,029	—	—	Acquired (1,619,059 owned after)	EDGAR
ONC	Wang Lai	President, Global Head of R&D	Award	2026-03-06	112,606	—	—	Acquired (1,564,030 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Award	2026-03-06	326,976	—	—	Acquired (5,491,339 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2026-02-04	662	$213.32	$141,218	Acquired (1,164 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2026-02-04	502	$194.47	$97,624	Acquired (502 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2026-02-04	496	$159.03	$78,879	Acquired (1,660 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Sale 10b5-1	2026-02-04	664	$348.79	$231,597	Disposed (996 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Sale 10b5-1	2026-02-04	996	$350.00	$348,600	Disposed (0 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Sale 10b5-1	2026-01-07	664	$331.76	$220,289	Disposed (0 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2026-01-07	202	$194.47	$39,283	Acquired (202 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2026-01-07	196	$159.03	$31,170	Acquired (664 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2026-01-07	266	$213.32	$56,743	Acquired (468 owned after)	EDGAR
ONC	Wang Lai	President, Global Head of R&D	Award	2025-12-31	427,895	—	—	Acquired (1,451,424 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2025-12-16	40	$305.24	$12,210	Disposed (0 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2025-12-16	1,877	$300.80	$564,597	Disposed (22,492 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2025-12-16	600	$300.98	$180,586	Disposed (21,892 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2025-12-16	2,567	$301.79	$774,699	Disposed (19,325 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2025-12-16	1,512	$302.31	$457,097	Disposed (17,813 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2025-12-16	7,470	$302.74	$2,261,492	Disposed (10,343 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2025-12-16	1,633	$303.13	$495,013	Disposed (8,710 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2025-12-16	5,442	$303.72	$1,652,855	Disposed (3,268 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2025-12-16	1,255	$304.13	$381,685	Disposed (2,013 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2025-12-16	1,973	$304.36	$600,507	Disposed (40 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2025-12-15	14,163	$308.41	$4,368,018	Disposed (55,925 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2025-12-15	2,344	$311.33	$729,749	Disposed (26,613 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2025-12-15	121	$311.93	$37,743	Disposed (26,492 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2025-12-15	929	$313.52	$291,256	Disposed (25,563 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2025-12-15	1,194	$314.92	$376,009	Disposed (24,369 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2025-12-15	5,118	$307.38	$1,573,168	Disposed (70,088 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2025-12-15	10,650	$309.37	$3,294,798	Disposed (45,275 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2025-12-15	4,949	$306.39	$1,516,335	Disposed (75,206 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2025-12-15	3,940	$305.55	$1,203,867	Disposed (80,155 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2025-12-15	5,829	$304.37	$1,774,160	Disposed (84,095 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2025-12-15	1,896	$303.60	$575,629	Disposed (89,924 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2025-12-15	6,389	$302.29	$1,931,331	Disposed (91,820 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2025-12-15	16,318	$310.48	$5,066,489	Disposed (28,957 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2025-12-15	1,791	$301.58	$540,127	Disposed (98,209 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Sale 10b5-1	2025-12-11	332	$325.00	$107,900	Disposed (0 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2025-12-11	98	$159.03	$15,585	Acquired (332 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2025-12-11	133	$213.32	$28,372	Acquired (234 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2025-12-11	101	$194.47	$19,641	Acquired (101 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Sale 10b5-1	2025-12-10	332	$318.28	$105,669	Disposed (0 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2025-12-10	101	$194.47	$19,641	Acquired (101 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2025-12-10	133	$213.32	$28,372	Acquired (234 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2025-12-10	98	$159.03	$15,585	Acquired (332 owned after)	EDGAR
ONC	Sanders Corazon (Corsee) D.	Director	Sale	2025-11-26	1,823	$340.20	$620,185	Disposed (804 owned after)	EDGAR
ONC	Sanders Corazon (Corsee) D.	Director	Option exercise	2025-11-26	2,627	$159.03	$417,772	Acquired (2,627 owned after)	EDGAR
ONC	Sanders Corazon (Corsee) D.	Director	Sale	2025-11-26	804	$342.47	$275,349	Disposed (0 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale	2025-11-17	3,155	$380.23	$1,199,617	Disposed (836 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale	2025-11-17	10	$382.32	$3,823	Disposed (0 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale	2025-11-17	826	$381.19	$314,862	Disposed (10 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale	2025-11-13	4,240	$380.33	$1,612,583	Disposed (1,769 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale	2025-11-13	1,769	$381.05	$674,077	Disposed (0 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2025-11-12	398	$213.32	$84,901	Acquired (700 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Sale 10b5-1	2025-11-12	664	$348.75	$231,570	Disposed (332 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2025-11-12	296	$159.03	$47,073	Acquired (996 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale	2025-11-12	154	$362.07	$55,759	Disposed (6,009 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale	2025-11-12	4,846	$360.10	$1,745,024	Disposed (6,163 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale	2025-11-12	100	$357.43	$35,743	Disposed (11,009 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale	2025-11-12	120	$355.00	$42,600	Disposed (11,109 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale	2025-11-12	251	$354.20	$88,903	Disposed (11,229 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale	2025-11-12	789	$352.78	$278,341	Disposed (11,480 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale	2025-11-12	3,240	$351.41	$1,138,569	Disposed (12,269 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale	2025-11-12	500	$350.44	$175,220	Disposed (15,509 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Gift	2025-11-12	858,533	—	—	Disposed (6,441,041 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Sale 10b5-1	2025-11-12	332	$350.00	$116,200	Disposed (0 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2025-11-12	302	$194.47	$58,730	Acquired (302 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Gift	2025-11-11	151,320	—	—	Disposed (7,299,574 owned after)	EDGAR
ONC	Wang Xiaodong	Director	Gift	2025-11-07	424,073	—	—	Disposed (4,582,601 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Sale 10b5-1	2025-10-08	4,733	$350.22	$1,657,580	Disposed (4,162 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Sale 10b5-1	2025-10-08	4,162	$351.12	$1,461,375	Disposed (0 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Sale 10b5-1	2025-10-08	664	$347.82	$230,952	Disposed (8,895 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Sale 10b5-1	2025-10-08	1,112	$350.00	$389,200	Disposed (0 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2025-10-08	302	$194.47	$58,730	Acquired (302 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2025-10-08	8,961	$213.32	$1,911,561	Acquired (9,263 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2025-10-08	296	$159.03	$47,073	Acquired (9,559 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2025-09-16	12,446	$326.14	$4,059,091	Disposed (4,408 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2025-09-16	4,008	$326.90	$1,310,227	Disposed (400 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2025-09-16	4,066	$324.12	$1,317,862	Disposed (23,737 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2025-09-16	6,883	$325.06	$2,237,402	Disposed (16,854 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2025-09-16	400	$327.78	$131,112	Disposed (0 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Sale 10b5-1	2025-09-10	300	$326.80	$98,040	Disposed (500 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Sale 10b5-1	2025-09-10	500	$327.93	$163,965	Disposed (0 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2025-09-10	6,802	$194.47	$1,322,785	Acquired (6,802 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2025-09-10	1,796	$213.32	$383,123	Acquired (8,598 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2025-09-10	296	$159.03	$47,073	Acquired (8,894 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Sale 10b5-1	2025-09-10	4,776	$325.19	$1,553,124	Disposed (4,118 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Sale 10b5-1	2025-09-10	3,318	$325.73	$1,080,760	Disposed (800 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Sale 10b5-1	2025-09-10	1,112	$325.00	$361,400	Disposed (0 owned after)	EDGAR
ONC	Wang Xiaodong	Director	Gift	2025-09-09	148,096	—	—	Disposed (5,006,674 owned after)	EDGAR
ONC	Wang Lai	Global Head of R&D	Sale 10b5-1	2025-09-09	5,000	$350.06	$1,750,312	Disposed (0 owned after)	EDGAR
ONC	Sanders Corazon (Corsee) D.	Director	Option exercise	2025-09-05	2,665	$155.68	$414,887	Acquired (2,665 owned after)	EDGAR
ONC	Sanders Corazon (Corsee) D.	Director	Sale	2025-09-05	2,665	$337.00	$898,105	Disposed (0 owned after)	EDGAR
ONC	Ball Titus B.	Principal Accounting Officer	Sale	2025-09-02	122	$326.76	$39,865	Disposed (0 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale 10b5-1	2025-08-14	5,800	$302.04	$1,751,857	Disposed (33,736 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Option exercise 10b5-1	2025-08-14	9,180	$159.03	$1,459,895	Acquired (39,936 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Option exercise 10b5-1	2025-08-14	30,756	$155.68	$4,788,094	Acquired (30,756 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale 10b5-1	2025-08-14	600	$308.03	$184,819	Disposed (0 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale 10b5-1	2025-08-14	4,917	$307.43	$1,511,626	Disposed (600 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale 10b5-1	2025-08-14	12,232	$306.26	$3,746,189	Disposed (5,517 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale 10b5-1	2025-08-14	8,522	$305.48	$2,603,297	Disposed (17,749 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale 10b5-1	2025-08-14	500	$304.19	$152,097	Disposed (26,271 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale 10b5-1	2025-08-14	6,965	$303.31	$2,112,586	Disposed (26,771 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale 10b5-1	2025-08-14	400	$300.86	$120,345	Disposed (39,536 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Option exercise 10b5-1	2025-08-13	27,085	$155.68	$4,216,593	Acquired (49,858 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2025-08-13	3,849	$159.03	$612,106	Acquired (8,230 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Option exercise 10b5-1	2025-08-13	4,381	$194.47	$851,973	Acquired (4,381 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Sale 10b5-1	2025-08-13	1,112	$300.00	$333,600	Disposed (0 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Option exercise 10b5-1	2025-08-13	22,773	$174.43	$3,972,294	Acquired (22,773 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale 10b5-1	2025-08-13	8,900	$300.33	$2,672,962	Disposed (40,958 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale 10b5-1	2025-08-13	4,500	$301.49	$1,356,703	Disposed (36,458 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale 10b5-1	2025-08-13	5,800	$302.45	$1,754,194	Disposed (30,658 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale 10b5-1	2025-08-13	3,517	$303.54	$1,067,564	Disposed (27,141 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale 10b5-1	2025-08-13	7,359	$304.37	$2,239,887	Disposed (19,782 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale 10b5-1	2025-08-13	528	$305.59	$161,352	Disposed (19,254 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale 10b5-1	2025-08-13	9,637	$306.74	$2,956,094	Disposed (9,617 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale 10b5-1	2025-08-13	9,617	$307.38	$2,956,062	Disposed (0 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Sale 10b5-1	2025-08-13	6,052	$300.19	$1,816,724	Disposed (2,178 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Sale 10b5-1	2025-08-13	3,849	$301.00	$1,158,553	Disposed (0 owned after)	EDGAR
ONC	Rosenberg Aaron	Chief Financial Officer	Sale	2025-08-01	1,190	$290.47	$345,659	Disposed (0 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Sale	2025-07-30	920	$304.60	$280,233	Disposed (0 owned after)	EDGAR
ONC	Wang Lai	Global Head of R&D	Sale 10b5-1	2025-07-30	259	$305.00	$78,995	Disposed (0 owned after)	EDGAR
ONC	Wang Lai	Global Head of R&D	Sale 10b5-1	2025-07-29	800	$304.16	$243,330	Disposed (259 owned after)	EDGAR
ONC	Wang Lai	Global Head of R&D	Sale 10b5-1	2025-07-29	292	$302.92	$88,454	Disposed (1,059 owned after)	EDGAR
ONC	Wang Lai	Global Head of R&D	Sale 10b5-1	2025-07-29	2,949	$302.00	$890,596	Disposed (1,351 owned after)	EDGAR
ONC	Wang Lai	Global Head of R&D	Sale 10b5-1	2025-07-18	700	$300.00	$210,000	Disposed (0 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2025-07-09	1,553	$254.83	$395,757	Disposed (0 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2025-07-09	10,254	$254.10	$2,605,577	Disposed (1,553 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2025-07-09	9,292	$253.18	$2,352,575	Disposed (11,807 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale 10b5-1	2025-07-09	6,703	$252.23	$1,690,682	Disposed (21,099 owned after)	EDGAR
ONC	Wang Xiaodong	Director	Sale 10b5-1	2025-06-24	507	$266.57	$135,149	Disposed (100 owned after)	EDGAR
ONC	Wang Xiaodong	Director	Sale 10b5-1	2025-06-24	300	$263.50	$79,050	Disposed (1,707 owned after)	EDGAR
ONC	Wang Xiaodong	Director	Sale 10b5-1	2025-06-24	1,100	$265.35	$291,888	Disposed (607 owned after)	EDGAR
ONC	Wang Xiaodong	Director	Sale 10b5-1	2025-06-24	100	$267.81	$26,781	Disposed (0 owned after)	EDGAR
ONC	Wang Lai	Global Head of R&D	Sale	2025-06-23	1,028	$260.00	$267,280	Disposed (0 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale	2025-06-23	3,074	$261.57	$804,070	Disposed (100 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale	2025-06-23	100	$262.90	$26,290	Disposed (0 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale	2025-06-23	1,363	$260.00	$354,380	Disposed (0 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale	2025-06-17	1,460	$256.49	$374,473	Disposed (0 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale	2025-06-17	630	$250.87	$158,047	Disposed (0 owned after)	EDGAR
ONC	Wang Lai	Global Head of R&D	Sale	2025-06-17	470	$251.37	$118,142	Disposed (0 owned after)	EDGAR
ONC	Wang Lai	Global Head of R&D	Sale	2025-06-16	1,177	$266.40	$313,558	Disposed (470 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Sale	2025-06-16	422	$266.50	$112,463	Disposed (0 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale	2025-06-16	3,680	$266.05	$979,046	Disposed (1,460 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale	2025-06-16	1,443	$265.47	$383,072	Disposed (730 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale	2025-06-16	100	$266.22	$26,622	Disposed (630 owned after)	EDGAR
ONC	Ball Titus B.	Principal Accounting Officer	Sale	2025-06-11	134	$258.36	$34,620	Disposed (0 owned after)	EDGAR
ONC	Wang Xiaodong	Director	Sale 10b5-1	2025-06-10	15,878	$262.20	$4,163,262	Disposed (22,981 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Award	2025-06-10	46,878	—	—	Acquired (283,920 owned after)	EDGAR
ONC	Ball Titus B.	Principal Accounting Officer	Award	2025-06-10	29,601	—	—	Acquired (73,983 owned after)	EDGAR
ONC	Wang Xiaodong	Director	Sale 10b5-1	2025-06-10	16,094	$263.17	$4,235,501	Disposed (6,887 owned after)	EDGAR
ONC	Wang Xiaodong	Director	Sale 10b5-1	2025-06-10	6,787	$264.08	$1,792,314	Disposed (100 owned after)	EDGAR
ONC	Wang Xiaodong	Director	Sale 10b5-1	2025-06-10	100	$264.85	$26,485	Disposed (0 owned after)	EDGAR
ONC	Yi Qingqing	Director	J	2025-06-10	29,614	—	—	Disposed (27,326 owned after)	EDGAR
ONC	Wang Lai	Global Head of R&D	Award	2025-06-10	86,359	—	—	Acquired (1,058,304 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Award	2025-06-10	123,370	—	—	Acquired (1,274,296 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Award	2025-06-10	185,055	—	—	Acquired (8,281,841 owned after)	EDGAR
ONC	Wang Xiaodong	Director	Award 10b5-1	2025-06-10	98,696	—	—	Acquired (5,180,861 owned after)	EDGAR
ONC	Wang Xiaodong	Director	Option exercise 10b5-1	2025-06-10	41,760	$6.50	$271,440	Acquired (41,760 owned after)	EDGAR
ONC	Wang Xiaodong	Director	Sale 10b5-1	2025-06-10	2,901	$261.20	$757,753	Disposed (38,859 owned after)	EDGAR
ONC	Rosenberg Aaron	Chief Financial Officer	Award	2025-06-10	63,674	—	—	Acquired (230,802 owned after)	EDGAR
ONC	Wang Lai	Global Head of R&D	Sale	2025-06-06	600	$250.71	$150,425	Disposed (802 owned after)	EDGAR
ONC	Wang Lai	Global Head of R&D	Sale	2025-06-06	202	$251.89	$50,882	Disposed (600 owned after)	EDGAR
ONC	Wang Lai	Global Head of R&D	Sale	2025-06-06	300	$253.19	$75,956	Disposed (300 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale	2025-06-06	400	$250.74	$100,294	Disposed (1,534 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale	2025-06-06	500	$251.85	$125,926	Disposed (1,034 owned after)	EDGAR
ONC	Wu Xiaobin	President and COO	Sale	2025-06-06	234	$255.77	$59,850	Disposed (0 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Sale	2025-06-06	230	$256.79	$59,063	Disposed (0 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale	2025-06-06	400	$255.74	$102,295	Disposed (0 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale	2025-06-06	927	$254.97	$236,358	Disposed (400 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale	2025-06-06	1,000	$253.49	$253,490	Disposed (1,327 owned after)	EDGAR
ONC	OYLER JOHN	Chief Executive Officer	Sale	2025-06-06	1,400	$250.84	$351,177	Disposed (3,727 owned after)	EDGAR
ONC	Lee Chan Henry	SVP, General Counsel	Sale	2025-06-06	470	$255.78	$120,217	Disposed (230 owned after)	EDGAR
ONC	BAKER BROS. ADVISORS LP	Director	Award	2025-05-21	21,970	—	—	Acquired (148,065 owned after)	EDGAR
ONC	BAKER BROS. ADVISORS LP	Director	Sale	2025-02-28	671,976	$260.00	$174,713,760	Disposed (8,068,411 owned after)	EDGAR
ONC	BAKER BROS. ADVISORS LP	Director	Sale	2025-02-28	60,851	$260.00	$15,821,260	Disposed (730,642 owned after)	EDGAR

Long US-equity 13F disclosures only · up to 45-day reporting lag · sells = reduce/avoid, not short. JSON: /api/signals · /api/funds · /api/status